The scientific exploration of saliva in the post-proteomic era: from database back to basic function

S Ruhl - Expert review of proteomics, 2012 - Taylor & Francis
The proteome of human saliva can be considered as being essentially completed.
Diagnostic markers for a number of diseases have been identified among salivary proteins
and peptides, taking advantage of saliva as an easy-to-obtain biological fluid. Yet, the

Host defense proteins derived from human saliva bind to Staphylococcus aureus

SM Heo, KS Choi, LA Kazim, MS Reddy… - Infection and …, 2013 - Am Soc Microbiol
ABSTRACT Proteins in human saliva are thought to modulate bacterial colonization of the
oral cavity. Yet, information is sparse on how salivary proteins interact with systemic
pathogens that transiently or permanently colonize the oral environment. Staphylococcus

Top-down platform for deciphering the human salivary proteome

M Castagnola, T Cabras, F Iavarone… - The Journal of …, 2012 - Taylor & Francis
Proteomic platforms can be classified in bottom-up strategies, which analyze the sample
after proteolytic digestion, and top-down strategies, which analyze the intact naturally
occurring proteome. Bottom-up platforms are high-throughput because they can investigate

The salivary proteome: challenges and perspectives

WL Siqueira, C Dawes - PROTEOMICS-Clinical Applications, 2011 - Wiley Online Library
Abstract We provide a brief overview of the salivary proteome but with an emphasis on the
major challenges in protein identification and quantitation. Precautions are necessary to
avoid proteolysis, deglycosylation and dephosphorylation of salivary proteins by microbial

The human salivary proteome: a critical overview of the results obtained by different proteomic platforms

M Castagnola, T Cabras, F Iavarone… - Expert review of …, 2012 - Taylor & Francis
The development of new separation techniques and different mass spectrometry
instrumental devices, as well as the great availability of specific reactants, offers ample
choice to scientists for carrying out high-throughput proteomic studies and being competitive

Defining salivary biomarkers using mass spectrometry-based proteomics: a systematic review

SK Al-Tarawneh, MB Border… - Omics: a journal of …, 2011 -
Abstract Recent advancements in mass spectrometric proteomics provide a promising result
in utilizing saliva to explore biomarkers for diagnostic purposes. However, the issues of
specificity or redundancy of disease-associated salivary biomarkers have not been

Whole-saliva proteolysis and its impact on salivary diagnostics

K Thomadaki, EJ Helmerhorst, N Tian… - Journal of dental …, 2011 -
There is growing interest in the use of human whole saliva for diagnostics and disease
monitoring as an alternative to blood samples. In contrast to blood, whole saliva is a non-
sterile body fluid. Proper hand-ling and storage are required to preserve the integrity of

Identification of glycoprotein receptors within the human salivary proteome for the lectin‐like BabA and SabA adhesins of Helicobacter pylori by fluorescence‐based 2 …

A Walz, S Odenbreit, K Stühler, A Wattenberg… - …, 2009 - Wiley Online Library
Abstract Because gastric infection by Helicobacter pylori takes place via the oral route,
possible interactions of this bacterium with human salivary proteins could occur. By using
modified 1-and 2-D bacterial overlay, binding of H. pylori adhesins BabA and SabA to the

Identification of Lys-Pro-Gln as a novel cleavage site specificity of saliva-associated proteases

EJ Helmerhorst, X Sun, E Salih… - Journal of Biological …, 2008 - ASBMB
Abstract The nonsterile environment of the oral cavity facilitates substantial proteolytic
processing, not only of resident salivary proteins but also of dietary proteins. To gain insight
into whole saliva enzymatic processes, the in vivo generated peptides in this oral fluid were

[CITATION][C] Ксеростомия. Этиология и патогенез в свете современных представлений

ТП Терешина - Дентальные технологии, 2006