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17335380[PMID] - PMC - NCBI

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1.
Figure 3

Figure 3. From: Actinobacillus actinomycetemcomitans Lipopolysaccharide-Mediated Experimental Bone Loss Model for Aggressive Periodontitis.

μCT shows A. actinomycetemcomitans LPS induced significant linear bone loss. A) Reformatted μCT isoform display from 8-week A. actinomycetemcomitans LPS-injected rat maxillae exhibits dramatic palatal and interproximal bone loss. B) Linear bone loss as measured from the CEJ to the ABC. Significant bone loss (*P < 0.01) was observed between control (N = 6) and A. actinomycetemcomitans LPS (Aa LPS)-injected rats (N = 12).

Jill E. Rogers, et al. J Periodontol. ;78(3):550-558.
2.
Figure 4

Figure 4. From: Actinobacillus actinomycetemcomitans Lipopolysaccharide-Mediated Experimental Bone Loss Model for Aggressive Periodontitis.

A. actinomycetemcomitans LPS induced significant loss of proximal bone volume. A) Reformatted μCT isoform display showing volumetric ROI used for analysis. B) Analysis of μCT volumes were assessed using software. Data are presented as percentage bone within ROI. Significant bone loss (*P < 0.001) was observed between control (N = 6) and A. actinomycetemcomitans LPS (Aa LPS)-injected rats (N = 12).

Jill E. Rogers, et al. J Periodontol. ;78(3):550-558.
3.
Figure 6

Figure 6. From: Actinobacillus actinomycetemcomitans Lipopolysaccharide-Mediated Experimental Bone Loss Model for Aggressive Periodontitis.

A. actinomycetemcomitans LPS delivery enhanced osteoclastogenesis. A) Histologic sections were stained for TRAP. Arrows indicate TRAP-positive cells in A. actinomycetemcomitans LPS (Aa LPS)-injected rats. B) Stained cells that were TRAP-positive and had three or more nuclei were enumerated. LPS-injected animals (N = 12) exhibited significantly more TRAP-positive cells than control animals (N = 6; *P = 0.0023). (Scale bar = 1μm; original magnification × 60.)

Jill E. Rogers, et al. J Periodontol. ;78(3):550-558.
4.
Figure 2

Figure 2. From: Actinobacillus actinomycetemcomitans Lipopolysaccharide-Mediated Experimental Bone Loss Model for Aggressive Periodontitis.

A. actinomycetemcomitans LPS induced more inflammatory cell infiltrate into the area adjacent to bone loss. Histologic appearance of representative control at low magnification (A), and at high magnification (B), enlarged box area from A shows normal structure with minimal inflammatory cells. A. actinomycetemcomitans LPS-injected rat periodontal tissues at low magnification (C), and at high magnification (D), enlarged box area from C shows significant inflammatory infiltrate is present.

Jill E. Rogers, et al. J Periodontol. ;78(3):550-558.
5.
Figure 5

Figure 5. From: Actinobacillus actinomycetemcomitans Lipopolysaccharide-Mediated Experimental Bone Loss Model for Aggressive Periodontitis.

Pronounced expression of proinflammatory cytokines was observed in A. actinomycetemcomitans LPS (Aa LPS)-injected animals. Histologic sections were immunostained and detected using Nova Red reagent for IL-6 (A), IL-1β (C), or TNF-α (E). B, D, and F) Immunohistochemical (IHC) scores from control animals and 8 weeks post-LPS injections. Significant differences were observed for IL-6 (*P = 0.0104) and TNF-α (*P = 0.0305) and approached significant differences between control and LPS-treated groups for IL-1β (P = 0.0671). (Original magnification × 60.)

Jill E. Rogers, et al. J Periodontol. ;78(3):550-558.
6.
Figure 1

Figure 1. From: Actinobacillus actinomycetemcomitans Lipopolysaccharide-Mediated Experimental Bone Loss Model for Aggressive Periodontitis.

Characterization of A. actinomycetemcomitans LPS used in these studies. A) Purified A. actinomycetemcomitans LPS demonstrated characteristic laddering on a silver nitrate–stained polyacrylamide gel with indicated quantities of A. actinomycetemcomitans LPS. B) Absence of protein as indicated by Coomassie-stained gel with the same LPS. C) Matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectra showing singly charged anions representing the major lipid A structures present. The major peak corresponds to the hexa-acylated form (mass-to-charge ratio [m/z] at 1,827) with minor forms being present as well.

Jill E. Rogers, et al. J Periodontol. ;78(3):550-558.

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