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Recognition of immunoglobulin A1 by oral actinomyces and streptococcal lectins. - PubMed - NCBI
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Infect Immun. 1996 Dec;64(12):5421-4.

Recognition of immunoglobulin A1 by oral actinomyces and streptococcal lectins.

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1
Laboratory of Microbial Ecology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA.

Abstract

Actinomyces naeslundii and Streptococcus gordonii, oral bacteria that possess Gal/GalNAc- and sialic acid-reactive lectins, respectively, were adherent to immobilized secretory immunoglobulin A (IgA) and two IgA1 myeloma proteins but not to two IgA2 myeloma proteins. Apparently, O-linked oligosaccharides at the hinge region of the IgA1 heavy chain are receptors for lectin-mediated adhesion of these bacteria.

PMID:
8945600
PMCID:
PMC174542
[Indexed for MEDLINE]
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