University at Buffalo - The State University of New York
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Molecular Interactions - Medical Scientist Training Program - University at Buffalo
University at Buffalo - The State University of New York
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Core Facilities

Molecular Interactions

Mark Sutton, PhD

Mark Sutton, PhD, helps maintain the Molecular Interactions facility, which has instrumentation for acquiring high quality kinetic, affinity and thermodynamic data.

Our facility offers powerful, analytical instrumentation used to study macromolecular interactions.

We have instrumentation ideal for acquiring high quality kinetic, affinity and thermodynamic data for biomolecular interactions.

Our facility enables you to achieve direct, label-free measurement of binding affinity and thermodynamics of biomolecules in a single experiment.

Isothermal Titration Calorimetry — a technique used in quantitative studies of a wide variety of biomolecular interactions — requires no modification of binding partners, either with fluorescent tags or through immobilization. It measures the affinity of binding partners in their native states including ligand binding to live cells or to ligand binding sites incorporated into synthetic vesicles or particles.

Instrumentation

  • Reichert SR7000DC System Processing Unit surface plasmon resonance based technology for studying biomolecular interactions in real time
  • MicroCal Isothermal Calorimeter quantifies heat released or absorbed in the equilibrium binding of ligand to macromolecule, or the interaction between two macromolecules

Locations

Reichert SPR
404 Biomedical Research Building

MicroCal ITC
656 Biomedical Research Building

Contact Information

Reichert SPR

Sutton, Mark

Mark Sutton, PhD

Professor

651 Biomedical Research Building, 3435 Main Street Buffalo, NY 14214

Phone: (716) 829-3581; Fax: (716) 829-2661

Email: mdsutton@buffalo.edu

MicroCal ITC

Kosman, Daniel

Daniel Kosman, PhD

SUNY Distinguished Professor

653 Biomedical Education Building, 140 Farber Hall (mailing address) Buffalo, NY 14214

Phone: (716) 829-2842; Fax: (716) 829-2661

Email: camkos@buffalo.edu