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The Clinical Proteomic Technologies for Cancer | Details for Mitogen-Activated Protein Kinase Kinase 1 Peptide 3

Mitogen-Activated Protein Kinase Kinase 1 Peptide 3


Background

Catalog Number:

CPTC-MAP2K1 -2

Target Antigen:

Mitogen-Activated Protein Kinase Kinase 1 Peptide 3

Isotype:

IgG2b

Species:

Mouse Monoclonal Antibody

Last Updated:

08/22/2016

Antigen Recognition(s):

peptide

Characterization Data [Compare Characterization Data]
  IPMS

CPTC-MAP2K1-2 iMRM

Immuno-MRM chromatogram of CPTC-MAP2K1-2 antibody with CPTC-MAP2K1 peptide 3 (NCI ID#129) as target

Background

Catalog Number:

CPTC-MAP2K1-1

Target Antigen:

Mitogen-Activated Protein Kinase Kinase 1 Peptide 3

Isotype:

IgG3

Species:

Mouse Monoclonal Antibody

Last Updated:

08/22/2016

Antigen Recognition(s):

peptide

Characterization Data [Compare Characterization Data]
  IPMS

CPTC-MAP2K1-1 iMRM

Immuno-MRM chromatogram of CPTC-MAP2K1-1 antibody with CPTC-MAP2K1 peptide 3 (NCI ID#129) as target

Background

NCI Identification Number:

00129

Antigen Name:

Mitogen-Activated Protein Kinase Kinase 1 Peptide 3

CPTC Name:

CPTC-MAP2K1 Peptide 3

Keywords:

Mitogen-Activated Protein Kinase Kinase 1; ERK Activator Kinase 1; MAPK/ERK Kinase 1; EC 2.7.12.2; MAPKK 1; PRKMK1; MEK 1; MEK1; MKK1; Protein Kinase, Mitogen-Activated, Kinase 1 (MAP Kinase Kinase 1); MAP Kinase Kinase 1; MAPKK1; CFC3

Function:

The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.

MAP2K1 (Mitogen-Activated Protein Kinase Kinase 1) is a Protein Coding gene. Diseases associated with MAP2K1 include cardiofaciocutaneous syndrome 3 and cardiofaciocutaneous syndrome. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Signaling by GPCR. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP2K2.

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis

Chromosomal Localization:

15q22.33

Expression System:

NCBI Accession Number:

NP_002746.1

Swiss Prot Accession Number:

Q02750

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

ISELGAGNGGVVFK

Native Sequence:

Calculated Isoelectric Point:

0

Molecular Weight:

1540

Last Updated:

07/12/2016

Links

Characterization Data

SOPs

No SOPs available.

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