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Int J Clin Exp Med. 2014 Aug 15;7(8):2369-72. eCollection 2014.

Embryonal rhabdomyosarcoma of the paranasal sinuses: a case report and review of literature.

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Department of Clinical Medcine, The Fourth Affiliated Hospital of Nanchang University Nanchang, Jiangxi 330003, China.
Department of Pathology, Taiping People's Hospital of Dongguan, The Fifth People's Hospital of Dongguan Dongguan 523905, China.
Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guandong Medical College Dongguan 523808, China.
Department of Pathology, Sun Yat-Sen University Cancer Center Guanzhou 510060, China.
Department of Otolaryngology, Affiliated Hospital of Guandong Medical College Zhanjiang 524023, China.


Embryonal rhabdomyosarcoma (ERMS) is a rare malignancy with a poor outcome. In this article, we describe a case of ERMS in the paranasal sinuses from a 60-year-old male patient. ERMS derived from the paranasal sinuses is extremely rare. The diagnosis of ERMS must be based on histological findings and immunohistochemical findings. In this case, microscopic observation showed tumor cells were arranged in flocked sheets, cord-like and acinar-like by hyperplastic fibrous tissue. And ERMS tissues were immunopositive for myogenin, desmin, MSA, CD56, vimentin, CD99, Syn and Ki-67 (40%+), and immunonegative for CK, EMA, LCA, GFAP, NSE, S-100, HMB-45 and Melan-A. Here, the patient was treated with multimodal therapy including endoscopic surgery, chemotherapy and radiation, but the patient's postoperative recovery is not too smooth.


Embryonal rhabdomyosarcoma; immunohistochemistry; paranasal sinuses

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