Epigenetic transgenerational actions of endocrine disruptors and male fertility

MD Anway, AS Cupp, M Uzumcu, MK Skinner - science, 2005 - science.sciencemag.org
Abstract Transgenerational effects of environmental toxins require either a chromosomal or
epigenetic alteration in the germ line. Transient exposure of a gestating female rat during the
period of gonadal sex determination to the endocrine disruptors vinclozolin (an

Crystal structure of rat liver dihydropteridine reductase

KI Varughese, MM Skinner… - Proceedings of the …, 1992 - National Acad Sciences
Abstract The structure of a binary complex of dihydropteridine reductase [DHPR; NAD (P) H:
6, 7-dihydropteridine oxidoreductase, EC 1.6. 99.7] with its cofactor, NADH, has been solved
and refined to a final R factor of 15.4% by using 2.3 A diffraction data. DHPR is an

Structure of the gene V protein of bacteriophage f1 determined by multiwavelength x-ray diffraction on the selenomethionyl protein

MM Skinner, H Zhang, DH Leschnitzer… - Proceedings of the …, 1994 - National Acad Sciences
Abstract The crystal structure of the dimeric gene V protein of bacteriophage f1 was
determined using multiwavelength anomalous diffraction on the selenomethionine-
containing wild-type and isoleucine-47--> methionine mutant proteins with x-ray diffraction

[HTML][HTML] Homo naledi, a new species of the genus Homo from the Dinaledi Chamber, South Africa

…, HM Garvin, SA Williams, JM DeSilva, MM Skinner… - Elife, 2015 - elifesciences.org
Abstract Homo naledi is a previously-unknown species of extinct hominin discovered within
the Dinaledi Chamber of the Rising Star cave system, Cradle of Humankind, South Africa.
This species is characterized by body mass and stature similar to small-bodied human

Dental tissue proportions and enamel thickness in Neandertal and modern human molars

…, J Radovčić, MM Skinner, M Toussaint… - Journal of Human …, 2008 - Elsevier
The thickness of dental enamel is often discussed in paleoanthropological literature,
particularly with regard to differences in growth, health, and diet between Neandertals and
modern humans. Paleoanthropologists employ enamel thickness in paleodietary and

Dental trait expression at the enamel-dentine junction of lower molars in extant and fossil hominoids

MM Skinner, BA Wood, C Boesch, AJ Olejniczak… - Journal of Human …, 2008 - Elsevier
Discrete dental traits are used as proxies for biological relatedness among modern human
populations and for alpha taxonomy and phylogeny reconstruction within the hominin clade.
We present a comparison of the expression of lower molar dental traits (cusp 6, cusp 7,

Endocrine disruptor vinclozolin induced epigenetic transgenerational adult-onset disease

MD Anway, C Leathers, MK Skinner - Endocrinology, 2006 - academic.oup.com
The fetal basis of adult disease is poorly understood on a molecular level and cannot be
solely attributed to genetic mutations or a single etiology. Embryonic exposure to
environmental compounds has been shown to promote various disease states or lesions in

Epigenetic transgenerational actions of endocrine disruptors

MD Anway, MK Skinner - Endocrinology, 2006 - academic.oup.com
Abstract Endocrine disruptors have recently been shown to promote an epigenetic
transgenerational phenotype involving a number of disease states (eg male infertility). The
anti-androgenic fungicide vinclozolin was found to act transiently at the time of embryonic

Neandertals made the first specialized bone tools in Europe

…, W Rendu, M Richards, MM Skinner… - Proceedings of the …, 2013 - National Acad Sciences
Abstract Modern humans replaced Neandertals∼ 40,000 y ago. Close to the time of
replacement, Neandertals show behaviors similar to those of the modern humans arriving
into Europe, including the use of specialized bone tools, body ornaments, and small blades.

Transgenerational epigenetic imprints on mate preference

…, T Schallert, MD Anway, MK Skinner - Proceedings of the …, 2007 - National Acad Sciences
Abstract Environmental contamination by endocrine-disrupting chemicals (EDC) can have
epigenetic effects (by DNA methylation) on the germ line and promote disease across
subsequent generations. In natural populations, both sexes may encounter affected as well