University at Buffalo - The State University of New York
Skip to Content
Photofrin photodynamic therapy for treatment of AIDS-related cutaneous Kaposi's sarcoma. - PubMed - NCBI
Format

Send to

Choose Destination
See comment in PubMed Commons below
AIDS. 1999 Sep 10;13(13):1697-704.

Photofrin photodynamic therapy for treatment of AIDS-related cutaneous Kaposi's sarcoma.

Author information

1
Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.

Abstract

OBJECTIVE:

Kaposi's sarcoma, the most common malignancy in AIDS patients, often presents with painful cutaneous lesions that are difficult to treat effectively despite a wide variety of therapeutic approaches. We used photodynamic therapy in an attempt to provide effective palliative treatment for this disease.

METHODS:

Photodynamic therapy utilizes the activation by light of a photosensitizing drug that preferentially accumulates in tumor tissue such as Kaposi's sarcoma. We enrolled 25 patients who received 1.0 mg/kg of Photofrin 48 h before exposure to 100-400 J/cm2 of 630 nm light.

RESULTS:

Of the 348 lesions treated, 289 were evaluable: 32.5% had complete clinical response, 63.3% had partial clinical response and 4.2% were clinical failures. There was a strong correlation between response and light dose: 54% of lesions achieved a complete clinical response at optimum light dose (> 250 J/cm2). There was no correlation of response with CD4 cell count nor was there a change in CD4 cell count post-treatment. At 400 J/cm2 full field scabbing and necrosis occurred in 90% of the treated fields. Thus, the maximum tolerated dose was determined to be 300 J/cm2. At light doses of 250 J/cm2 and below the toxicities were limited to erythema and edema in the treatment field. Forty-three biopsies were taken 0.5 h to 4 months post-treatment. These showed little change in the B and T cell infiltrates identified. Kaposi's sarcoma cells disappeared post-treatment in certain lesions.

CONCLUSION:

Photofrin is effective palliative treatment for HIV-associated Kaposi's sarcoma.

PMID:
10509571
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wolters Kluwer
    Loading ...
    Support Center