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NCBI Conserved Domain Search
NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Search for Conserved Domains within a protein or coding nucleotide sequence
Use Batch CD-search to submit multiple query proteins at once!

Enter protein or nucleotide query as accession, gi, or sequence in FASTA format


Use cdart db on server:

Use database at:

Search against database:

Expect Value threshold:

Apply low-complexity filter

Composition based statistics adjustment

Rescue borderline hits  Suppress weak overlapping hits

Maximum number of hits

Result modeConciseStandardFull

Retrieve previous CD-search result
Request ID:


  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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