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PubMed Central, Figure 4: Nat Cell Biol. 2014 Oct; 16(10): 1004–13. Published online 2014 Sep 21. doi:  10.1038/ncb3040
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PMC full text:
Nat Cell Biol. Author manuscript; available in PMC 2015 Apr 1.
Published in final edited form as:
Nat Cell Biol. 2014 Oct; 16(10): 1004–13.
Published online 2014 Sep 21. doi:  10.1038/ncb3040

Figure 4

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ΔNp63-mediated MaSC function is dependent on Fzd7

(a) Quantification of colonies formed by P4 cells transduced with indicated lentiviruses (n = 3 samples; data represents mean ± s.d.). (b) P4 cells were transduced with control or Fzd7 lentiviruses and limiting numbers of cells were transplanted into cleared fat pads. Table shows take rate quantifications. (c) Quantification of colonies formed by P4 cells from WT and ΔNp63gfp/+ mice with or without Fzd7 overexpression (n = 5 samples; data represents mean ± s.d.). (d) Representative images of colonies from c. (e) Table showing reconstitution efficiency at limiting dilution of P4 cells from WT and ΔNp63gfp/+ mice with Fzd7 overexpression. (f) Representative images and pie graph summary of outgrowths from e. (g) Table showing reconstitution efficiency at limiting dilution of P4 cells from control and ΔNp63 overexpressing cells with or without Fzd7 KD. (h) Representative images and pie graph summary of outgrowths from g. ● 80–100%, An external file that holds a picture, illustration, etc.
Object name is nihms622121ig1.jpg 30–80%, ◔ 0–30% and ○ No reconstitution. *p < 0.05 by Student’s t test in a and c. In b, e, and g, n= number of mammary fat pad injections as indicated in tables. p value was obtained by Pearson’s Chi-squared test using ELDA software. Size bar, 1 mm in d and f, and 2 mm in h, respectively.

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