[HTML][HTML] Biological, clinical, and population relevance of 95 loci for blood lipids

…, SW Fouchier, A Isaacs, GM Peloso, M Barbalic… - Nature, 2010 - ncbi.nlm.nih.gov
Abstract Serum concentrations of total cholesterol, low-density lipoprotein cholesterol (LDL-
C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) are among the most
important risk factors for coronary artery disease (CAD) and are targets for therapeutic

[HTML][HTML] Analysis of protein-coding genetic variation in 60,706 humans

…, AL Moonshine, P Natarajan, L Orozco, GM Peloso… - Nature, 2016 - ncbi.nlm.nih.gov
Summary Large-scale reference data sets of human genetic variation are critical for the
medical and functional interpretation of DNA sequence changes. We describe the
aggregation and analysis of high-quality exome (protein-coding region) sequence data for

[HTML][HTML] Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

BF Voight, GM Peloso, M Orho-Melander… - The Lancet, 2012 - Elsevier
BACKGROUND: High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes
are randomly assigned at meiosis, are independent of non-genetic confounding, and are

Common variants at 30 loci contribute to polygenic dyslipidemia

S Kathiresan, CJ Willer, GM Peloso, S Demissie… - Nature …, 2009 - nature.com
Abstract Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL)
cholesterol and triglyceride levels are risk factors for cardiovascular disease. To dissect the
polygenic basis of these traits, we conducted genome-wide association screens in 19,840

Common variants associated with plasma triglycerides and risk for coronary artery disease

…, EM Schmidt, S Sengupta, C Gao, GM Peloso… - Nature …, 2013 - nature.com
Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in
epidemiological studies, increased triglyceride levels correlate with higher risk for coronary
artery disease (CAD). However, it is unclear whether this association reflects causal

[HTML][HTML] Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia

…, JP Pirruccello, R Do, GM Peloso… - … England Journal of …, 2010 - Mass Medical Soc
We sequenced all protein-coding regions of the genome (the “exome”) in two family
members with combined hypolipidemia, marked by extremely low plasma levels of low-
density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and

[HTML][HTML] Genetic associations with valvular calcification and aortic stenosis

…, JG Smith, AV Smith, GM Peloso… - … England Journal of …, 2013 - Mass Medical Soc
Background Limited information is available regarding genetic contributions to valvular
calcification, which is an important precursor of clinical valve disease. Methods We
determined genomewide associations with the presence of aortic-valve calcification (among

[HTML][HTML] A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study

…, DK Arnett, GM Peloso… - BMC medical …, 2007 - bmcmedgenet.biomedcentral.com
Background Blood lipid levels including low-density lipoprotein cholesterol (LDL-C), high-
density lipoprotein cholesterol (HDL-C), and triglycerides (TG) are highly heritable. Genome-
wide association is a promising approach to map genetic loci related to these heritable

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction

…, O Zuk, I Guella, R Asselta, LA Lange, GM Peloso… - Nature, 2015 - nature.com
Myocardial infarction (MI), a leading cause of death around the world, displays a complex
pattern of inheritance1, 2. When MI occurs early in life, genetic inheritance is a major
component to risk1. Previously, rare mutations in low-density lipoprotein (LDL) genes have

[HTML][HTML] The early repolarization pattern in the general population: clinical correlates and heritability

…, L Oikarinen, A Pietilä, K Harald, GM Peloso… - Journal of the American …, 2011 - Elsevier
... RR interval, ms, 1,004 ± 164, 1,076 ± 189, 966 ± 153, 1,030 ± 174, 987 ± 170, 1,072 ± 167,
961 ± 149, 1,000 ± 175. Height, m, 1.78 ± 0.07, 1.77 ± 0.06, 1.64 ± 0.06, 1.65 ± 0.06, 1.76 ±
0.07, 1.78 ± 0.06, 1.63 ± 0.07, 1.63 ± 0.07. Weight, kg, 89.2 ± 16.1, 84.2 ± 15.2, 70.4 ± 16.9,