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Faculty Profile - Jacobs School of Medicine and Biomedical Sciences - University at Buffalo
University at Buffalo - The State University of New York
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Harvey                         Berman

Harvey A. Berman PhD, MPH

Department of Pharmacology and Toxicology

Associate Professor

Specialty/Research Focus

Molecular and Cellular Biology; Neuropharmacology; Protein Function and Structure

 

Education and Training:
  • MPH, Epidemiology, SUNY at Buffalo (2010)
  • PhD, Chemistry, University of Massachusetts (1974)
  • BS, Chemistry, Brooklyn College of CUNY (1966)
Employment:
  • Associate Professor, Pharmacology and Toxicology, SUNY at Buffalo (2000-present)
  • Associate Professor, Biochemical Pharmacology, SUNY at Buffalo (1987–2000)
  • Assistant Professor, Biochemical Pharmacology, SUNY at Buffalo (1981–1987)
  • Assistant Research Pharmacologist & Lecturer, Dept. of Medicine - Pharmacology Division, University of California (1978–1982)
  • NIH Postdoctoral Fellow, Department of Medicine - Pharmacology, University of California (1975–1978)


Journal Articles:
  • Kovarik Z, Radic Z, Berman HA, Taylor P. Mutation of acetylcholinesterase to enhance oxime-assisted catalytic turnover of methylphosphonates. Toxicology. 2007; 233(1-3).
  • Luo ZD, Berman HA. Pb2+-mediated down-regulation of dihydropyridine receptors in skeletal muscle. Toxicol Lett. 2004; 152(2).
  • Kovarik Z, Radic Z, Berman HA, Simeon-Rudolf V, Reiner E, Taylor P. Mutant cholinesterases possessing enhanced capacity for reactivation of their phosphonylated conjugates. Biochemistry. 2004; 43(11).
  • Kovarik Z, Radic Z, Berman HA, Simeon-Rudolf V, Reiner E, Taylor P. Acetylcholinesterase active centre and gorge conformations analysed by combinatorial mutations and enantiomeric phosphonates. Biochem J. 2003; 373(Pt 1).
  • Wong L, Radic Z, Br├╝ggemann RJ, Hosea N, Berman HA, Taylor P. Mechanism of oxime reactivation of acetylcholinesterase analyzed by chirality and mutagenesis.. Biochemistry. 2000; 39(19).
  • Taylor P, Wong L, Radic Z, Tsigelny I, Br├╝ggemann R, Hosea NA, Berman HA. Analysis of cholinesterase inactivation and reactivation by systematic structural modification and enantiomeric selectivity.. Chem Biol Interact. 1999; 119-1.
  • Luo ZD, Berman HA. The influence of Pb2+ on expression of acetylcholinesterase and the acetylcholine receptor.. Toxicol Appl Pharmacol. 1997; 145(2).
  • Phillips RR, Lee MY, Berman HA, Madoff MA. The Tufts partnership for managed care education.. Acad Med. 1997; 72(5).
  • Taylor P, Hosea NA, Tsigelny I, Radic Z, Berman HA. Determining ligand orientation and transphosphonylation mechanisms on acetylcholinesterase by Rp, Sp enantiomer selectivity and site-specific mutagenesis. Enantiomer. 1997; 2(3-4).
  • Hosea NA, Radic Z, Tsigelny I, Berman HA, Quinn DM, Taylor P. Aspartate 74 as a primary determinant in acetylcholinesterase governing specificity to cationic organophosphonates.. Biochemistry. 1996; 35(33).
  • Taylor P, Radic Z, Hosea NA, Camp S, Marchot P, Berman HA. Structural bases for the specificity of cholinesterase catalysis and inhibition.. Toxicol Lett. 1995; 82-83.
  • Hosea NA, Berman HA, Taylor P. Specificity and orientation of trigonal carboxyl esters and tetrahedral alkylphosphonyl esters in cholinesterases.. Biochemistry. 1995; 34(36).
  • Berman HA, Leonard K. Interaction of tetrahydroaminoacridine with acetylcholinesterase and butyrylcholinesterase.. Mol Pharmacol. 1992; 41(2).
  • Jo SA, Higgins DM, Berman HA. Regulation of acetylcholinesterase in avian heart. Studies on ontogeny and the influence of vagotomy.. Circ Res. 1992; 70.
  • Nowak MW, Berman HA. Fluorescence studies on the interactions of myelin basic protein in electrolyte solutions.. Biochemistry. 1991; 30(30).
  • Berman HA, Leonard K. Ligand exclusion on acetylcholinesterase.. Biochemistry. 1990; 29(47).
  • Decker MM, Berman HA. Denervation-induced alterations of acetylcholinesterase in denervated and nondenervated muscle.. Exp Neurol. 1990; 109(2).
  • Decker MM, Berman HA. Dihydropyridine receptor regulation of acetylcholinesterase biosynthesis.. J Biol Chem. 1990; 265(20).
  • Conti CR, Williams JF, Anderson JL, Berman HA, Gunnar RM, Herman GP, Lyons FW, Passamani ER, Reid PR, Silverman ME. Ethics in cardiovascular medicine. Task Force V: The relation of cardiovascular specialists to industry, institutions and organizations.. J Am Coll Cardiol. 1990; 16(1).
  • Berman HA, Decker MM. Chiral nature of covalent methylphosphonyl conjugates of acetylcholinesterase.. J Biol Chem. 1989; 264(7).
  • Berman HA, Leonard K. Chiral reactions of acetylcholinesterase probed with enantiomeric methylphosphonothioates. Noncovalent determinants of enzyme chirality.. J Biol Chem. 1989; 264(7).
  • Johnson DA, Brown RD, Herz JM, Berman HA, Andreasen GL, Taylor P. Decidium. A novel fluorescent probe of the agonist/antagonist and noncompetitive inhibitor sites on the nicotinic acetylcholine receptor.. J Biol Chem. 1987; 262(29).
  • Berman HA, Decker MM, Nowak MW, Leonard KJ, McCauley M, Baker WM, Taylor P. Site selectivity of fluorescent bisquaternary phenanthridinium ligands for acetylcholinesterase.. Mol Pharmacol. 1987; 31(6).
  • Berman HA, Decker MM, Jo S. Reciprocal regulation of acetylcholinesterase and butyrylcholinesterase in mammalian skeletal muscle.. Dev Biol. 1987; 120(1).
  • Edery H, Geyer MA, Taylor P, Berman HA. Target sites for anticholinesterases on the ventral surface of the medulla oblongata: hypotension elicited by organophosphorus agents.. J Auton Pharmacol. 1986; 6(3).
  • Berman HA, Decker MM. Kinetic, equilibrium, and spectroscopic studies on dealkylation ('aging') of alkyl organophosphonyl acetylcholinesterase. Electrostatic control of enzyme topography.. J Biol Chem. 1986; 261(23).
  • Berman HA, Decker MM. Kinetic, equilibrium, and spectroscopic studies on dealkylation ("aging") of alkyl organophosphonyl acetylcholinesterase. Electrostatic control of enzyme topography. J Biol Chem. 1986; 261(23).
  • Berman HA, Decker MM. Kinetic, equilibrium and spectroscopic studies on cation association at the active center of acetylcholinesterase: topographic distinction between trimethyl and trimethylammonium sites.. Biochim Biophys Acta. 1986; 872(1-2).
  • Berman HA, Yguerabide J, Taylor P. Flexibility of the molecular forms of acetylcholinesterase measured with steady-state and time-correlated fluorescence polarization spectroscopy.. Biochemistry. 1985; 24(25).
  • Edery H, Berman HA. Yohimbine antagonism of the vasodepression elicited by organophosphates applied on ventral medulla oblongata.. J Auton Nerv Syst. 1985; 14(3).
  • Berman HA, Olshefski DF, Gilbert M, Decker MM. Fluorescent phosphonate labels for serine hydrolases. Kinetic and spectroscopic properties of (7-nitrobenz-2-oxa-1,3-diazole)aminoalkyl methylphosphonofluoridates and their conjugates with acetylcholinesterase molecular forms.. J Biol Chem. 1985; 260(6).
  • Zheng S, Berman HA, Geyer MA. Behavior during hippocampal microinfusions: anticholinesterase-induced locomotor activation.. Behav Brain Res. 1983; 9(3).
  • Berman HA, Becktel W, Taylor P. Spectroscopic studies on acetylcholinesterase: influence of peripheral-site occupation on active-center conformation.. Biochemistry. 1981; 20(16).
  • Berman HA, Yguerabide J, Taylor P. Fluorescence energy transfer on acetylcholinesterase: spatial relationship between peripheral site and active center.. Biochemistry. 1980; 19(10).
  • Epstein DJ, Berman HA, Taylor P. Ligand-induced conformational changes in acetylcholinesterase investigated with fluorescent phosphonates.. Biochemistry. 1979; 18(21).
  • Berman HA, Taylor P. Fluorescent phosphonate label for serine hydrolases, pyrenebutyl methylphosphonofluoridate: reaction with acetylcholinesterase.. Biochemistry. 1978; 17(9).
  • Berman HA, Barza M, Weinstein L. Serum sulfonamide concentration after oral administration: comparison of results of chemical assay with two bioassay techniques.. Antimicrob Agents Chemother. 1972; 1(3).
  • Berman HA, Weinstein L. Antibiotics and nutrition.. Am J Clin Nutr. 1971; 24(2).
  • Berman HA, Weinstein L. Search for trichinella infection in Western Samoa and Fiji.. Med J Aust. 1970; 2(13).
  • Grossman W, Berman HA. Typhoid fever in the previously immunised.. Lancet. 1968; 2(7573).
  • Klocke RA, Augerson WS, Berman HH, Burgos FL, Rivera RA. Desquamative interstitial pneumonia. A disease with a wide clinical spectrum.. Ann Intern Med. 1967; 66(3).
  • Taylor P, Hosea NA, Tsigelny I, Radic Z, Berman HA. Determining ligand orientation and transphosphonylation mechanisms on acetylcholinesterase by Rp, Sp enantiomer selectivity and site-specific mutagenesis.. Enantiomer. ; 2(3-4).
  • Berman HA. Physicians must share in costs, savings.. Internist. ; 26(5).
See all (33 more)


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Contact Information

204 Sherman Hall
Buffalo, NY 14214
Phone: 716-829-2658
Fax: 716-829-2001
Email: hberman@buffalo.edu


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