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Efficacy of human salivary mucin MUC7-derived peptide and histatin 5 in a murine model of candidiasis. - PubMed - NCBI
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Int J Antimicrob Agents. 2003 Dec;22(6):594-600.

Efficacy of human salivary mucin MUC7-derived peptide and histatin 5 in a murine model of candidiasis.

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1
Departments of Oral Biology and Oral Diagnostic Sciences, School of Dental Medicine, University at Buffalo, The State University of New York, 109 Foster Hall, 3435 Main Street, Buffalo, NY 14214-3092, USA.

Abstract

MUC7 16-mer (residues 36-51 of human salivary mucin, MUC7) and histatin 5 possess potent in vitro antifungal activity. In the present study, we have evaluated the efficacy of these peptides in vivo using the experimental model of murine vulvo-vaginal candidiasis. The treatment groups included MUC7 16-mer, histatin 5, clotrimazole (all in pluronic F127 gel), and placebo (gel alone). Mice were treated intravaginally for 7 consecutive days. At the end of the treatment, anticandidal activities were assessed by colony counts and by histological examination. All groups except clotrimazole presented positive cultures; no statistically significant differences were found in fungal burden amongst placebo and any treatment group except clotrimazole. Histopathological findings confirmed the microbiological results; all groups with the exception of clotrimazole showed variable signs of infection.

PMID:
14659657
[Indexed for MEDLINE]
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