[HTML][HTML] Muc5b is required for airway defense

…, BR Grubb, WK O'Neal, SC Flores, A Cota-Gomez… - Nature, 2014 - ncbi.nlm.nih.gov
Abstract Respiratory surfaces are exposed to billions of particulates and pathogens daily. A
protective mucus barrier traps and eliminates them via mucociliary clearance (MCC) 1, 2.
However, excessive mucus contributes to transient respiratory infections and to the

HIV-1 Nef is associated with complex pulmonary vascular lesions in SHIV-nef–infected macaques

…, A Carville, RP Shannon, A Cota-Gomez… - American journal of …, 2006 - Am Thoracic Soc
Rationale: HIV-infected patients with pulmonary arterial hypertension have histologic
manifestations that are indistinguishable from those found in patients with idiopathic
pulmonary arterial hypertension. In addition, the role of pleiotropic viral proteins in the

Widespread colonization of the lung by Tropheryma whipplei in HIV infection

C Lozupone, A Cota-Gomez, BE Palmer… - American journal of …, 2013 - Am Thoracic Soc
Rationale: Lung infections caused by opportunistic or virulent pathogens are a principal
cause of morbidity and mortality in HIV infection. It is unknown whether HIV infection leads to
changes in basal lung microflora, which may contribute to chronic pulmonary complications

[HTML][HTML] A novel class of microbial phosphocholine‐specific phospholipases C

MJ Stonehouse, A CotaGomez… - Molecular …, 2002 - Wiley Online Library
Summary In this report we describe the 1500-fold purification and characterization of the
haemolytic phospholipase C (PLC) of Pseudomonas aeruginosa, the paradigm member of a
novel PLC/phosphatase superfamily. Members include proteins from Mycobacterium

The human immunodeficiency virus-1 Tat protein activates human umbilical vein endothelial cell E-selectin expression via an NF-κB-dependent mechanism

A Cota-Gomez, NC Flores, C Cruz, A Casullo… - Journal of Biological …, 2002 - ASBMB
Abstract Human immunodeficiency virus infection is associated with inflammation and
endothelial cell activation that cannot be ascribed to direct infection by the virus or to the
presence of opportunistic infections. Factors related to the virus itself, to the host and/or to

PlcR1 and PlcR2 are putative calcium-binding proteins required for secretion of the hemolytic phospholipase C of Pseudomonas aeruginosa.

A Cota-Gomez, AI Vasil, J Kadurugamuwa… - Infection and …, 1997 - Am Soc Microbiol
ABSTRACT The plcHR operon of Pseudomonas aeruginosa includes the structural gene for
the hemolytic phospholipase C, plcH (previously known as plcS), and two overlapping, in-
phase, genes designated plcR1 and plcR2. Hemolytic and phospholipase C (PLC) activities

Alterations in redox homeostasis and prostaglandins impair endothelial-dependent vasodilation in euglycemic autoimmune nonobese diabetic mice

X Ling, A Cota-Gomez, NC Flores… - Free Radical Biology …, 2005 - Elsevier
We report herein the novel observation that alterations in oxidant/antioxidant balance are
evident and cause vascular dysfunction in aortae of prediabetic nonobese-diabetic mice
(NOD). We found that nitrotyrosine, a biochemical marker of oxidant stress, was higher in the

HIV-1 Tat regulates the SOD2 basal promoter by altering Sp1/Sp3 binding activity

JC Marecki, A Cota-Gomez, GM Vaitaitis… - Free Radical Biology …, 2004 - Elsevier
Regulation of the basal manganese superoxide dismutase (SOD2) promoter depends on
the transcriptional activity of the Sp family of transcription factors. Here we report that
reduced expression in the presence of Tat is independent of induction with Tumor necrosis

HIV-1 Tat increases oxidant burden in the lungs of transgenic mice

A Cota-Gomez, AC Flores, XF Ling… - Free Radical Biology …, 2011 - Elsevier
Chronic human immunodeficiency virus infection is associated with higher incidence of
pulmonary complications including hypertension, vasculopathy, lymphocytic alveolitis, and
interstitial pneumonitis not attributed to either opportunistic infections or presence of the

Different roles of Sp family members in HIV-1 Tat-mediated manganese superoxide dismutase suppression in hepatocellular carcinoma cells

…, A Nath, V Prachayasittikul, A Cota-Gomez… - DNA and cell …, 2005 - online.liebertpub.com
The expression of manganese superoxide dismutase (MnSOD) is regulated by agents
associated with cancer development. It has been shown that infection with the human
immunodeficiency virus type 1 (HIV-1) is associated with the development of liver cancer