[HTML][HTML] Algorithms, data structures, and numerics for likelihood-based phylogenetic inference of huge trees

F Izquierdo-Carrasco, SA Smith… - BMC …, 2011 - bmcbioinformatics.biomedcentral …
Background The rapid accumulation of molecular sequence data, driven by novel wet-lab
sequencing technologies, poses new challenges for large-scale maximum likelihood-based
phylogenetic analyses on trees with more than 30,000 taxa and several genes. The three
main computational challenges are: numerical stability, the scalability of search algorithms,
and the high memory requirements for computing the likelihood. Results We introduce ...