[HTML][HTML] Understanding rare and common diseases in the context of human evolution

L Quintana-MurciĀ - Genome biology, 2016 - genomebiology.biomedcentral.com
Abstract The wealth of available genetic information is allowing the reconstruction of human
demographic and adaptive history. Demography and purifying selection affect the purge of
rare, deleterious mutations from the human population, whereas positive and balancing
selection can increase the frequency of advantageous variants, improving survival and
reproduction in specific environmental conditions. In this review, I discuss how theoretical ...