Advantageous diversity maintained by balancing selection in humans

FM Key, JC Teixeira, C de Filippo, AM Andrés - Current opinion in genetics …, 2014 - Elsevier
Most human polymorphisms are neutral or slightly deleterious, but some genetic variation is
advantageous and maintained in populations by balancing selection. Considered a rarity
and overlooked for years, balanced polymorphisms have recently received renewed
attention with several lines of evidence showing their relevance in human evolution. From
theoretical work on its role in adaptation to empirical studies that identify its targets, recent ...