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PubMed Central, Figure 5: Oncogene. 2016 Nov 3; 35(44): 5781–5794. Published online 2016 May 2. doi:  10.1038/onc.2016.112
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PMC full text:
Oncogene. Author manuscript; available in PMC 2016 Nov 7.
Published in final edited form as:
Oncogene. 2016 Nov 3; 35(44): 5781–5794.
Published online 2016 May 2. doi:  10.1038/onc.2016.112

Figure 5

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TNF-α modulates expression of a global gene repertoire bound by cREL, p63α, and TAp73

RNA was isolated from cells treated with TNF-α for 1, 3, 6, 12, and 24 h and the differential gene expression was examined by an Illumina bead-based array. (A) Differential expression of up- and down-regulated genes in UM-SCC46 cells under basal level conditions when compared with normal human oral keratinocyte cells, and (B) altered gene expression of UM-SCC46 cells upon TNF-α treatment. The colored sections represent the percentages of differentially expressed genes with binding activities for cREL, p63, or TAp73. (C) Gene numbers with individual and intersecting binding activities among the three TFs at the basal level, or (D) after TNF-α treatment. Top Venn diagrams represent up-regulated genes, and bottom Venn diagrams represent down-regulated genes. (E) Heat maps of hierarchical cluster analysis of 46 up-regulated (left) and 27 down-regulated (right) genes with overlapped TF binding activities induced by TNF-α. Red, increased expression; blue, decreased expression (compared with untreated controls). Color key, Z-score, reflects the relationship of the value of gene expression in a specific sample to the mean of the expression values of the same gene in all the samples. Euclidean distance with complete linkage was used to constitute the gene cluster.

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