[HTML][HTML] Gut microbiota, metabolites and host immunity

MG Rooks, WS Garrett - Nature reviews. Immunology, 2016 - ncbi.nlm.nih.gov
Abstract The microbiota—the collection of microorganisms that live within and on all
mammals—provides crucial signals for the development and function of the immune system.
Increased availability of technologies that profile microbial communities is facilitating the

A global genetic interaction network maps a wiring diagram of cellular function

M Costanzo, B VanderSluis, EN Koch… - …, 2016 - science.sciencemag.org
RESULTS We tested most of the~ 6000 genes in the yeast Saccharomyces cerevisiae for all
possible pairwise genetic interactions, identifying nearly 1 million interactions, including~
550,000 negative and~ 350,000 positive interactions, spanning~ 90% of all yeast genes.

[HTML][HTML] Genetic determinants of the gut microbiome in UK twins

JK Goodrich, ER Davenport, M Beaumont… - Cell host & …, 2016 - Elsevier
Summary Studies in mice and humans have revealed intriguing associations between host
genetics and the microbiome. Here we report a 16S rRNA-based analysis of the gut
microbiome in 1,126 twin pairs, a subset of which was previously reported. Tripling the

[HTML][HTML] Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota

J Wang, LB Thingholm, J Skiecevičienė, P Rausch… - Nature …, 2016 - ncbi.nlm.nih.gov
Abstract Human gut microbiota is an important determinant for health and disease, and
recent studies emphasize the numerous factors shaping its diversity. Here we performed a
genome-wide association study (GWAS) of the gut microbiota using two cohorts from

The effect of host genetics on the gut microbiome

MJ Bonder, A Kurilshikov, EF Tigchelaar, Z Mujagic… - Nature …, 2016 - nature.com
Supplementary Table 3) and a total of 33 loci were associated with functional units, with 21
loci associated with MetaCyc pathways and 12 loci associated with GO2000 groups (Fig. 2,
Supplementary Figs. 2 and 3, and Supplementary Table 3), at P< 5× 10− 8 (false discovery

Cross-species comparisons of host genetic associations with the microbiome

JK Goodrich, ER Davenport, JL Waters, AG Clark… - …, 2016 - science.sciencemag.org
Abstract Recent studies in human populations and mouse models reveal notable
congruences in gut microbial taxa whose abundances are partly regulated by host
genotype. Host genes associating with these taxa are related to diet sensing, metabolism,

[HTML][HTML] Gut microbiome of coexisting BaAka Pygmies and Bantu reflects gradients of traditional subsistence patterns

A Gomez, KJ Petrzelkova, MB Burns, CJ Yeoman… - Cell reports, 2016 - Elsevier
Summary To understand how the gut microbiome is impacted by human adaptation to
varying environments, we explored gut bacterial communities in the BaAka rainforest hunter-
gatherers and their agriculturalist Bantu neighbors in the Central African Republic. Although

Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity

M Pigeyre, FT Yazdi, Y Kaur, D Meyre - Clinical science, 2016 - clinsci.org
Abstract In high-, middle-and low-income countries, the rising prevalence of obesity is the
underlying cause of numerous health complications and increased mortality. Being a
complex and heritable disorder, obesity results from the interplay between genetic

Gynecologic health and disease in relation to the microbiome of the female reproductive tract

KA Green, SM Zarek, WH Catherino - Fertility and sterility, 2015 - Elsevier
It is well established that the vagina is colonized by bacteria that serve important roles in
homeostasis. Imbalances in the proportion of bacteria may lead to a predisposition to
infection or reproductive complications. Molecular-based approaches demonstrated a

Microbiota and neurological disorders: a gut feeling

WH Moos, DV Faller, DN Harpp… - BioResearch open …, 2016 - online.liebertpub.com
Abstract In the past century, noncommunicable diseases have surpassed infectious
diseases as the principal cause of sickness and death, worldwide. Trillions of commensal
microbes live in and on our body, and constitute the human microbiome. The vast majority of