A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences

M Kimura - Journal of molecular evolution, 1980 - Springer
Summary Some simple formulae were obtained which enable us to estimate evolutionary
distances in terms of the number of nucleotide substitutions (and, also, the evolutionary rates
when the divergence times are known). In comparing a pair of nucleotide sequences, we
distinguish two types of differences; if homologous sites are occupied by different nucleotide
bases but both are purines or both pyrimidines, the difference is called type I (or “transition ...