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Molecular chaperones and the regulation of neurotransmitter exocytosis

By:Zinsmaier, KE (Zinsmaier, KE); Bronk, P (Bronk, P)

BIOCHEMICAL PHARMACOLOGY

Volume: 62

Issue: 1

Pages: 1-11

DOI: 10.1016/S0006-2952(01)00648-7

Published: JUL 1 2001

Abstract

Regulated neurotransmitter release depends on a precise sequence of events that lead to repeated cycles of exocytosis and endocytosis. These events are mediated by a series of molecular interactions among vesicular, plasma membrane, and cytosolic proteins. An emerging theme has been that molecular chaperones may guide the sequential restructuring of stable or transient protein complexes to promote a temporal and spatial regulation of the endo- and exocytotic machinery and to ensure a vectorial passage through the vesicle cycle. Chaperones, specialized for a few substrates, are ideally suited to participate in regulatory processes that require some molecular dexterity to rearrange conformational or oligomeric protein structures. This article emphasizes the significance of three molecular chaperone systems in regulated neurotransmitter release: the regulation of soluble NSF attachment protein receptor (SNARE) complexes by N-ethylmaleimide-sensitive factor (NSF) and the soluble NSF attachment protein (SNAP), the uncoating of clathrin-coated vesicles by the 70 kDa heat-shock cognate protein (Hsc70), and the regulation of SNARE complex-associated protein interactions by cysteine-string protein and Hsc70. (C) 2001 Elsevier Science Inc. All rights reserved.

Author Information

Reprint Address: Zinsmaier, KE (reprint author)

Univ Penn, Sch Med, Dept Neurosci, 234D Stemmler Hall, Philadelphia, PA 19104 USA.

Addresses:

[ 1 ] Univ Penn, Sch Med, Dept Neurosci, Philadelphia, PA 19104 USA

Funding
Funding AgencyGrant Number
NIMH NIH HHS 
MH12611F31 
NINDS NIH HHS 
R01NS38274 
Publisher

PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND

Categories / Classification

Research Areas:Pharmacology & Pharmacy

Web of Science Categories:Pharmacology & Pharmacy

Document Information

Document Type:Editorial Material

Language:English

Accession Number: WOS:000169096800001

PubMed ID: 11377391

ISSN: 0006-2952

Other Information

IDS Number: 439EA

Cited References in Web of Science Core Collection: 168

Times Cited in Web of Science Core Collection: 59

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