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Lasers Surg Med. 1990;10(5):485-8.

Cutaneous phototoxic occurrences in patients receiving Photofrin.

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Photodynamic Therapy Center, Roswell Park Cancer Institute, Buffalo, NY 14263.


Incidence of cutaneous phototoxic reactions induced by intravenous injection of Photofrin polyporphyrin was assessed in a series of 180 patients (266 injections) undergoing photodynamic therapy (PDT) at Roswell Park Cancer Institute during the period 1986-1989. In addition to the usual verbal questions regarding phototoxic reactions solicited at follow-up, forty-two patients in this group also responded to a written questionnaire designed to solicit answers to specific questions. Photofrin doses ranged from 0.5 to 2.0 mg/kg. Overall, 20-40% of patients reported some type of phototoxic response.

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