[HTML][HTML] A model-based approach for identifying signatures of ancient balancing selection in genetic data

M DeGiorgio, KE Lohmueller, R Nielsen - PLoS genetics, 2014 - journals.plos.org
Abstract While much effort has focused on detecting positive and negative directional
selection in the human genome, relatively little work has been devoted to balancing
selection. This lack of attention is likely due to the paucity of sophisticated methods for
identifying sites under balancing selection. Here we develop two composite likelihood ratio
tests for detecting balancing selection. Using simulations, we show that these methods ...