User profiles for author:Charles author:Lee

Charles Lee, Ph.D., FACMG

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Charles MC Lee

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[HTML][HTML] Global variation in copy number in the human genome

…, C Tyler-Smith, NP Carter, H Aburatani, C Lee… - nature, 2006 -
Abstract Copy number variation (CNV) of DNA sequences is functionally significant but has
yet to be fully ascertained. We have constructed a first-generation CNV map of the human
genome through the study of 270 individuals from four populations with ancestry in Europe,

MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling

…, AM Rogers, F Cappuzzo, T Mok, C Lee… - …, 2007 -
Abstract The epidermal growth factor receptor (EGFR) kinase inhibitors gefitinib and erlotinib
are effective treatments for lung cancers with EGFR activating mutations, but these tumors
invariably develop drug resistance. Here, we describe a gefitinib-sensitive lung cancer cell

Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer

…, X Cao, J Tchinda, R Kuefer, C Lee… - …, 2005 -
Recurrent chromosomal rearrangements have not been well characterized in common
carcinomas. We used a bioinformatics approach to discover candidate oncogenic
chromosomal aberrations on the basis of outlier gene expression. Two ETS transcription

Inferring trade direction from intraday data

C Lee, MJ Ready - The Journal of Finance, 1991 - Wiley Online Library
ABSTRACT This paper evaluates alternative methods for classifying individual trades as
market buy or market sell orders using intraday trade and quote data. We document two
potential problems with quote-based methods of trade classification: quotes may be

[CITATION][C] Detection of large-scale variation in the human genome

…, PK Donahoe, Y Qi, SW Scherer, C Lee - Nature …, 2004 - Nature Publishing Group

[PDF][PDF] A strategic contingencies' theory of intraorganizational power

DJ Hickson, CR Hinings, CA Lee, RE Schneck… - Administrative science …, 1971 - JSTOR
A strategic contingencies' theory of intraorganizational power is presented in which it is
hypothesized that organizations, being systems of interdependent subunits, have a power
distribution with its sources in the division of labor. The focus is shifted from the vertical-

Investor sentiment and the closed‐end fund puzzle

C Lee, A Shleifer, RH Thaler - The Journal of Finance, 1991 - Wiley Online Library
ABSTRACT This paper examines the proposition that fluctuations in discounts of closed-end
funds are driven by changes in individual investor sentiment. The theory implies that
discounts on various funds move together, that new funds get started when seasoned funds

Price momentum and trading volume

C Lee, B Swaminathan - the Journal of Finance, 2000 - Wiley Online Library
Abstract This study shows that past trading volume provides an important link between
“momentum” and “value” strategies. Specifically, we find that firms with high (low) past
turnover ratios exhibit many glamour (value) characteristics, earn lower (higher) future

Toward an implied cost of capital

WR Gebhardt, C Lee… - Journal of accounting …, 2001 - Wiley Online Library
Abstract In this study, we propose an alternative technique for estimating the cost of equity
capital. Specifically, we use a discounted residual income model to generate a market
implied cost-of-capital. We then examine firm characteristics that are systematically related

[HTML][HTML] Consensus statement: chromosomal microarray is a first-tier clinical diagnostic test for individuals with developmental disabilities or congenital anomalies

…, K Kok, ID Krantz, RM Kuhn, C Lee… - The American Journal of …, 2010 - Elsevier
Chromosomal microarray (CMA) is increasingly utilized for genetic testing of individuals with
unexplained developmental delay/intellectual disability (DD/ID), autism spectrum disorders
(ASD), or multiple congenital anomalies (MCA). Performing CMA and G-banded karyotyping