Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema

…, CD Cool, DA Lynch, SC Flores… - American journal of …, 2001 - Am Thoracic Soc
Emphysema due to cigarette smoking is characterized by a loss of alveolar structures. We
hypothesize that the disappearance of alveoli involves apoptosis of septal endothelial cells
and a decreased expression of lung vascular endothelial growth factor (VEGF) and its

[HTML][HTML] Inflammation, growth factors, and pulmonary vascular remodeling

…, L Mouthon, JA Barberà, S Eddahibi, SC Flores… - Journal of the American …, 2009 - Elsevier
Inflammatory processes are prominent in various types of human and experimental
pulmonary hypertension (PH) and are increasingly recognized as major pathogenic
components of pulmonary vascular remodeling. Macrophages, T and B lymphocytes, and

Oxidative stress and apoptosis interact and cause emphysema due to vascular endothelial growth factor receptor blockade

…, D Salvemini, NF Voelkel, SC Flores - American journal of …, 2003 - Am Thoracic Soc
We have previously demonstrated that a failure of pulmonary endothelial cell survival
induced by vascular endothelial growth factor (VEGF) receptor blockade results in lung
alveolar septal cell apoptosis and emphysema. Because apoptosis and oxidative stress may

Oxidative stress in severe pulmonary hypertension

…, RM Tuder, MW Hopken, SC Flores… - American journal of …, 2004 - Am Thoracic Soc
Severe pulmonary hypertension (PH) occurs in a primary or “unexplained” form and in a
group of secondary forms associated with a number of diseases. Because the lung tissue
from patients with severe PH demonstrates complex vascular lesions, which contain

Comparison of the respiratory microbiome in healthy nonsmokers and smokers

…, K Crothers, JL Curtis, SC Flores… - American journal of …, 2013 - Am Thoracic Soc
Rationale: Results from 16S rDNA-encoding gene sequence–based, culture-independent
techniques have led to conflicting conclusions about the composition of the lower respiratory
tract microbiome. Objectives: To compare the microbiome of the upper and lower respiratory

Tat protein of human immunodeficiency virus type 1 represses expression of manganese superoxide dismutase in HeLa cells

SC Flores, JC Marecki, KP Harper… - Proceedings of the …, 1993 - National Acad Sciences
Abstract Using a HeLa cell line stably transfected with the tat gene from human
immunodeficiency virus type 1, we have found that the expression of the regulatory Tat
protein suppresses the expression of cellular Mn-containing superoxide dismutase (Mn-

[HTML][HTML] Muc5b is required for airway defense

…, KA Terrell, BR Grubb, WK O'Neal, SC Flores… - Nature, 2014 - ncbi.nlm.nih.gov
Abstract Respiratory surfaces are exposed to billions of particulates and pathogens daily. A
protective mucus barrier traps and eliminates them via mucociliary clearance (MCC) 1, 2.
However, excessive mucus contributes to transient respiratory infections and to the

Mitochondrial H2O2 regulates the angiogenic phenotype via PTEN oxidation

…, AE Aplin, YT Tai, J Aguirre-Ghiso, SC Flores… - Journal of Biological …, 2005 - ASBMB
Abstract Recent studies have demonstrated that the tumor suppressor PTEN (p hosphatase
and ten sin homolog deleted from chromosome 10), the antagonist of the
phosphosphoinositol-3-kinase (PI3K) signaling cascade, is susceptible to H 2 O 2-

A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone

JD Piganelli, SC Flores, C Cruz, J Koepp… - Diabetes, 2002 - Am Diabetes Assoc
Abstract We present here the first report of a metalloporphyrin-based antioxidant that can
prevent or delay the onset of autoimmune diabetes. Type 1 diabetes is an autoimmune
process whereby T-cells recognize pancreatic β-cell antigens and initiate a leukocyte

Oxidant stress, immune dysregulation, and vascular function in type I diabetes

…, K Haskins, SC Flores - Antioxidants & redox …, 2007 - online.liebertpub.com
Although high glucose is an important contributor to diabetic vasculopathies, complications
still occur in spite of tight glycemic control, suggesting that some critical event prior to or
concurrent with hyperglycemia may contribute to early vascular changes. Utilizing previously