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The Clinical Proteomic Technologies for Cancer | Details for Cyclin D1 Peptide 5

Cyclin D1 Peptide 5


Background

Catalog Number:

CPTC-CCND1-6

Target Antigen:

Cyclin D1 Peptide 5

Isotype:

IgG1

Species:

Mouse Monoclonal Antibody

Last Updated:

08/18/2016

Antigen Recognition(s):

peptide

Characterization Data [Compare Characterization Data]
  IPMS

CPTC-CCND1-6 iMRM

Immuno-MRM chromatogram of CPTC-CCND1-6 antibody with CPTC-CCND1 peptide 5 (NCI ID#00134) as target

Background

NCI Identification Number:

00134

Antigen Name:

Cyclin D1 Peptide 5

CPTC Name:

CPTC-CCND1 Peptide 5

Keywords:

Cyclin D1; B-Cell Lymphoma 1 Protein; B-Cell CLL/Lymphoma 1; BCL-1 Oncogene; PRAD1 Oncogene; PRAD1; BCL1; Cyclin D1 (PRAD1: Parathyroid Adenomatosis 1); Parathyroid Adenomatosis 1; G1/S-Specific Cyclin D1; D11S287E; U21B31; BCL-1

Function:

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

CCND1 (Cyclin D1) is a Protein Coding gene. Diseases associated with CCND1 include multiple myeloma and von hippel-lindau syndrome. Among its related pathways are Signaling by GPCR and Cell Cycle, Mitotic. GO annotations related to this gene include protein kinase activity and enzyme binding. An important paralog of this gene is CCND2.

Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.

Chromosomal Localization:

11q13

Expression System:

NCBI Accession Number:

NP_444284.1

Swiss Prot Accession Number:

P24385

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

ACQEQIEALLESSLR

Native Sequence:

Calculated Isoelectric Point:

0

Molecular Weight:

1650

Last Updated:

07/12/2016

Links

Characterization Data

SOPs

No SOPs available.

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