Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta …

…, PW Freed, JY Westcott, PM Henson - Journal of Clinical …, 1998 -
Abstract Apoptosis in vivo is followed almost inevitably by rapid uptake into adjacent
phagocytic cells, a critical process in tissue remodeling, regulation of the immune response,
or resolution of inflammation. Phagocytosis of apoptotic cells by macrophages has been

A receptor for phosphatidylserine-specific clearance of apoptotic cells

…, DM Rose, A Pearson, RAB Ezekewitz, PM Henson - Nature, 2000 -
Abstract The culmination of apoptosis in vivo is phagocytosis of cellular corpses. During
apoptosis, the asymmetry of plasma membrane phospholipids is lost, which exposes
phosphatidylserine externally 1, 2, 3, 4. The phagocytosis of apoptotic cells can be inhibited

Leukocyte-dependent histamine release from rabbit platelets

J Benveniste, PM Henson… - Journal of Experimental …, 1972 -
Abstract We have studied the leukocyte-dependent mechanism of histamine release (LDHR)
from rabbit platelets, a complement-independent mechanism which has been implicated in
the deposition of immune complexes in acute serum sickness of rabbits. It was found by

[HTML][HTML] Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-β1 secretion and the resolution of inflammation

MLN Huynh, VA Fadok, PM Henson - The Journal of clinical …, 2002 -
Abstract Ingestion of apoptotic cells in vitro by macrophages induces TGF-β1 secretion,
resulting in an anti-inflammatory effect and suppression of proinflammatory mediators. Here,
we show in vivo that direct instillation of apoptotic cells enhanced the resolution of acute

C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells

…, B Ghebrehiwet, VA Fadok, PM Henson - Journal of …, 2001 -
Removal of apoptotic cells is essential for maintenance of tissue homeostasis,
organogenesis, remodeling, development, and maintenance of the immune system,
protection against neoplasia, and resolution of inflammation. The mechanisms of this

[HTML][HTML] Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte

…, DL Bratton, PA Oldenborg, M Michalak, PM Henson - Cell, 2005 - Elsevier
Apoptotic-cell removal is critical for development, tissue homeostasis, and resolution of
inflammation. Although many candidate systems exist, only phosphatidylserine has been
identified as a general recognition ligand on apoptotic cells. We demonstrate here that

A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo

…, MC Carroll, JS Savill, PM Henson, M Botto… - Journal of …, 2000 -
The strongest susceptibility genes for the development of systemic lupus erythematosus
(SLE) in humans are null mutants of classical pathway complement proteins. There is a
hierarchy of disease susceptibility and severity according to the position of the missing

[PDF][PDF] The role of phosphatidylserine in recognition of apoptotic cells by phagocytes.

…, SC Frasch, ML Warner, PM Henson - Cell Death & …, 1998 -
Abstract Exposure of phosphatidylserine on the outer leaflet of the plasma membrane is a
surface change common to many apoptotic cells. Normally restricted to the inner leaflet,
phosphatidylserine appears as a result of decreased aminophospholipid translocase activity

Chemotactic response to human C3a and C5a anaphylatoxins

HN Fernandez, PM Henson, A Otani… - The Journal of …, 1978 - Am Assoc Immnol
Abstract Peptides C3a and C5a, also known as anaphylatoxins, are derived from C
components C3 and C5 and have previously been reported to exhibit chemotactic activity.
Virtually no data exist, however, regarding the relative potency of C3a or C5a for stimulating

[HTML][HTML] By binding SIRPα or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation

…, JA Nick, DR Voelker, KE Greene, PM Henson - Cell, 2003 - Elsevier
Surfactant proteins A and D (SP-A and SP-D) are lung collectins composed of two regions, a
globular head domain that binds PAMPs and a collagenous tail domain that initiates
phagocytosis. We provide evidence that SP-A and SP-D act in a dual manner, to enhance or