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 About Oral BiologyNew Home     November 27, 2014  

Shuying Yang  PhD

Department of Oral Biology

Associate Professor

Specialty/Research Focus

Microbiology; Oral Biology

Faculty Research Profile

 
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Education and Training:
  • Postdoctoral Fellow, Dentistry, The Forsythe Institute & Harvard School of Dental Medicine (2003)
  • Postdoctoral Fellow, Dentistry, University of Michigan (2002)
  • PhD, Molecular Biology and Immunology, Shanghai Second Military Medical University & Zhengzhou University (2000)
  • MS, Molecular Biology and Cancer Biology, Beijing Medical University & Zhengzhou University (1997)
  • MD, Clinical Medicine, ShanXi Medical University (1994)
Employment:
  • Associate Professor, Oral Biology, State Universty of New York at Buffalo (2014-present)
  • Assistant Professor, Oral Biology, State University of New York at Buffalo (2008-2014)
  • Staff Scientist, Cytokine Biology, The Forsyth Institute (2007-2008)
  • Instructor, Developmental Biology, Harvard School of Dental Medicine (2005-2008)
  • Staff Associate, Cytokine Biology, The Forsyth Institute (2003-2007)
  • Postdoctoral Fellow, Cytokine Biology, The Forsyth Institute (2002-2003)
  • Research Associate, Developmental Biology, Harvard School of Dental Medicine (2002-2003)
  • Postdoctoral Fellow, Periodontics/Prevention/Geriatrics, University of Michigan (2000-2002)
Awards and Honors:
  • UUP Individual Development Award (2014)
  • UUP Individual Development Award (2012)
  • Oral Presentation ‐ 2010 Annual Meeting of the American Society for B (2012)
  • NIDCR T32 fellowship (2007)
  • ASMBR Young Investigator Award and Oral Presentation (2007)
  • ASBMR Most Outstanding Abstract Award and Oral Presentation (2006)
  • Oral Presentation - Twenty-Fifth Annual Meeting of the ASBMR (2003)
  • Scientific and Technological Advancement Award (2000)

Grants and Sponsored Research:
  • August 2014-May 2019
    Function of Regulator of G protein signaling in aging skeleton
    NIH/NIA
    Role: Principal Investigator
  • August 2014-May 2014
    Function of Regulator of G protein signaling in aging skeleton
    NIH/NIA
    Role: Principal Investigator
    $1,059,267.00
  • June 2014-May 2019
    Regulation of skeletal development and homeostasis by IFT protein
    NIH/NIDCR
    Role: Principal Investigator
    $1,250,000.00
  • May 2014-April 2019
    Role of RGS12, a regulator of G protein signaling, in bone remodeling.
    NIH/NIAMS
    Role: Principal Investigator
    $1,195,000.00
  • March 2012-February 2015
    The role of IFT80 in bone formation
    NIAMS
    Role: Principal Investigator
    $150,000.00
  • January 2010-April 2011
    Engineering the Bioactivity of Absorbable Magnesium Implants for Fracture Fixation and Bone Defect Scaffolds: The Effect of Calcium Phosphate Coatings on In‐ Vitro Biocorrosion and Osteogenic Differentiation of Mesenchymal Stem Cells.
    OTA
    Role: Co-Principal Investigator
    $25,000.00
  • January 2010-May 2011
    Engineering the Bioactivity of Absorbable Magnesium Implants for Fracture Fixation and Bone Defect Scaffolds: The Effect of Calcium Phosphate Coatings on In-Vitro Biocorrosion and Osteogenic Differentiation of Mesenchymal Stem Cells
    Orthopedic Trauma Association
    Role: Co-Principal Investigator
    $25,000.00
  • August 2008-July 2011
    Regulation of [Ca2 ]i Oscillation and Osteoclast Differentiation by RGS12.
    NIH; NIAMS
    Role: Principal Investigator
    $275,250.00

Journal Articles:
  • David Keinan1,2, Shuying Yang1,3*, Robert E. Cohen2, Xue Yuan1, Tongjun Liu1, 4, Yi-Ping Li5. Regulator of G protein signaling proteins (RGSs) in bone Frontiers in bioscience (Landmark Ed). 2014; 1(19).
  • Intini G, Katsuragi Y, Kirkwood KL, Yang S. Alveolar bone loss: mechanisms, potential therapeutic targets, and interventions 2014; 26(1).
  • Keinan D, Yang S, Cohen RE, Yuan X, Liu T, Li YP. Role of regulator of G protein signaling proteins in bone. Front Biosci (Landmark Ed). 2014; 19.
  • Xue Yuan1, Rosa A Serra2, Shuying Yang1,3*. Function and regulation of primary cilia and intraflagellar transport proteins in the skeleton Ann N Y Acad Sci.. 2014.
  • Dicesare P, Fox WM, Hill MJ, Krishnan GR, Yang S, Sarkar D.. Cell-material interactions on biphasic polyurethane matrix J Biomed Mater Res A. 2013; 101(8).
  • He X, Dziak R, Mao K, Genco R, Swithart M, Li C, Yang S. Integration of a Novel Injectable Nano Calcium Sulfate/Alginate Scaffold and BMP2 Gene-Modified Mesenchymal Stem Cells for Bone Regeneration. Tissue Eng Part A. 2013; 19(3-4).
  • He X, Dziak R, Yuan X, Mao K, Genco R, Swihart M, Sarkar D, Li C, Wang C, Lu L, Andreadis S, Yang S.. BMP2 genetically engineered MSCs and EPCs promote vascularized bone regeneration in rat critical-sized calvarial bone defects PLoS One. 2013; 8(4).
  • Liu J, Mao K, Liu Z, Guo W, Wang X, Cui F, Mao K*, Yang S*. Injectable biocomposites for bone healing in rabbit femoral condyle defects PLoS One. 2013; 8(10).
  • Wang C, Yuan X, Yang S. IFT80 is essential for chondrocyte differentiation by regulating Hedgehog and Wnt signaling pathways Experimental Cell Research. 2013; 319(5).
  • Xue Yuan1, Yi-Ping Li3, Frank Scannepieco1, 2, Xiaoning He1,4, Merry Jo Oursler5, Xinping Zhang6, Jean Vacher7 , Chunyi Li1, Shuying Yang1,2 . Loss of Rgs12 in mice disrupts bone remodeling and protects LPS-mediated bone loss by regulating both osteoclast differentiation and function. PLoS Genetics. 2013.
  • Yang S, Li YP, Liu T, He X, Yuan X, Li C, Cao J, Kim Y. . Mx1-Cre mediated Rgs12 conditional knockout mice exhibit increased bone mass phenotype. Genesis. 2013; 51(3).
  • Wang W, Olson D, Liang G, Franceschi RT, Li C, Wang B, Wang SS, Yang S.. Collagen XXIV (Col24α1) promotes osteoblastic differentiation and mineralization through TGF-β/Smads signaling pathway. International Journal of Biology Science. 2012; 8(10).
  • Yang S, Wang C. The intraflagellar transport protein IFT80 is required for cilia formation and osteogenesis bone. 2012; 51(3).
  • Patel M, Yang S.. Advances in reprogramming somatic cells to induced pluripotent stem cells. Stem Cell Rev.. 2010; 6(367).
  • Soltanoff CS, Yang S, Chen W, Li YP. Signaling networks that control the lineage commitment and differentiation of bone cells Crit Rev Eukaryot Gene Expr. 2009; 19(1).
  • Chen, W, Yang S, Abe, Y, et al.. Cathepsin K Knockout Mice with a Pycnodysostotic Phenotype Reveal Novel Function of Cathepsin K as a Regulator of Osteoclast Survival Human Molecular Genetics. 2007; 16(4).
  • Huang, W, Yang S, Shao, J, Li, Y-P. Osteoblast Differentiation and Gene Regulation Frontiers in Bioscience. 2007; 12.
  • Yang S, Chen, W, Stashenko, P, Li, Y-P. RGS10A is a Critical Component in the RANKL-Evoked Signaling Pathway for Osteoclast Differentiation Journal of Cell Science. 2007; 120(Pt19).
  • Yang S, Yi-Ping, LI. RGS10 Null Mutation Impairs Osteoclast Differentiation Resulting From the Loss of [Ca2 ] i Oscillation Regulation Genes & Development. 2007; 21(14).
  • Yang S, Li, Y-P. RGS12 is Essential for Signaling by RANKL for Terminal Differentiation of Osteoclasts Journal of Bone and Mineral Research. 2006; 22(1).
  • Franceschi, RT, Yang S, Rutherford, RB, Krebsbach, PH, Zhao, M, Wang, D. Gene Therapy Approaches for Bone Regeneration Cells Tissues Organs. 2004; 176(1-3).
  • Kamolmatyakul, S, Chen, W, Yang S, et al.. Up Regulates Cathepsin K Gene Expression in Osteoclast Cells In Vitro Via the Tyrosine Kinase-NFkB Pathway Journal of Dental Research. 2004; 83(10).
  • Franceschi, RT, Xiao, G, Jiang, DI, Gopalakrishnan, R, Yang S, Reith, E. Multiple Signaling Pathways Converge on the Cbfa1/Runx2 Transcription Factor to Regulate Osteoblast Differentiation Connective Tissue Research. 2003; 44(Sup.1).
  • Yang S, Duan, FL, Pan, W, et al.. Co-Expression of TNFa, IFNB Gene Controlled by HLA-B7 Promoter Enhances Antitumor Effect Chin. J. Microbiol. & Immun.. 2003; 23(4).
  • Yang S, Wei, D, Wang, D, Phimphilai, M, Krebsbalh, PH, Franceschi, RT. In Vitro and In Vivo Synergistic Interaction Between the Runx2/Cbfa1 Transcription Factors and Bone Morphogenetic Protein-2 in Stimulating Osteoblast Differentiation Journal of Bone and Mineral Research. 2003; 18.
  • Yang S, Duan, FL, Lu, FM, et al.. Comparative Study on In Vivo Direct Intratumal Gene Transfer Cationic Liposome-TK and Nude HSV-TK Gene in Mice Chin. J. Gastroenter. & Hepatol.. 2002; 11(1).
  • Chang, GM, Duan, FL, Yang S, et al.. Killing Effect of Galactolipid Modified Liposome on Hepatocellular Carcinoma In Vitro Chin. J. of Cancer. 1999; 18(3).
  • Chang, GM, Duan, FL, Yang S, et al.. Experimental Study on Antitumor Activity of Neo-Lactolipid Modified Aclriamycin Liposome on SMMC-7721 Chin. J. of Gastroenter. & Hepatol.. 1999; 8(1).
  • Yang S, Cao, GW, Duan, FL, et al.. Construction of Adenoviral Vector Increasing Tumor Immunogenicity by Enhancing Gene Expression of TNFa, IFNB, MHC I Acad. J. Sec. Med. Univ.. 1999; 20(9).
  • Chang, GM, Duan, FL, Yang S, et al.. Experimental Studies on Galactolipid Modified Liposome Targeting to the Liver Chin. J. Nud. Med.. 1998; 18(4).
  • Sheng, JQ, Duan, FL, Yang S, et al.. Effect of Oral Administration with Letinan Liposome on Hepatocellular Carcinoma In Vivo Beijing Medical Journal. 1998; 20(s:s).
  • Sheng, JQ, Duan, FL, Yang S, et al.. Experimental Studies on the Anti-Tumor Effect of Liposome Containing Lentinan Combined with IL-2 Targeted Microphage Chin. J. of Exp. & Clin. Immun.. 1998; 10(5).
  • Sheng, JQ, Duan, FL, Yang S, et al.. Effect of Oral Administration with Letinan Liposome on NK Cell Activity In Vitro Chin. J. of Exp. & Chin. Immun.. 1998; 11(2).
  • Sheng, JQ, Yang S, Duan, FL. Immuno-Regulation Effect of Letinan Chin. J. of Gastroenter. & Hepatol.. 1998; 7(1).
  • Yang S, Duan, FL. Killing Mechanisms of Suicide Gene System Chin. J. Gastroenter. & Hepatol.. 1998; 7(2).
  • Yang S, Duan, FL, Cao, GW, et al.. Construction of Retroviral Vector Carry the IRES Linked Tumor Necrosis Factor Alpha and Interferon Beta cDNAs Under the Control of HLA-B7 Inducible Promoter Chin. J. Gastroenter. & Hepatol.. 1998; 7(4).
  • Yang S, Duan, FL, Lu, FM, et al.. The Effect of Anti-Hepatocellular Carcinoma of HSV-tk Gene Therapy Mediated by Cationic Liposome In Vitro and In Vivo Chin. J. Cancer Biotherapy. 1998; 5(2).
  • Zhao, ZG, Duan, FL, Yang S, et al.. Effect of Anti-Hepatocellular Carcinoma of MLV-rIL-2, TIL, CY In Vivo Chin. J. of Cancer Biotherapy. 1998; 5(1).
  • Yang S, Duan, FL, Lu, FM. Transcriptional Regulatory Sequences of a-Fetoprotein Chin. J. Gastroenter. & Hepatol.. 1997; 6(3).
  • Yang S, Duan, FL, Lu, FM. Effect and Mechanism on Anti-Hepatocellular Carcinoma of Suicide Gene Mediated by SA Cationic Liposome J. of Henan Med. Univ.. 1997; 32(Suppl).
  • Yang S, Duan, FL, Lu, FM, et al.. Primary Study on Mechanisms of Bystander Effect Caused by Expression of Suicide Gene Chin. J. Gastroenter. & Hepatol.. 1997; 6(4).
See All (41 Total) >

Abstracts:
  • Wang C, Yang S. Essential role of Intraflagellar transport 80 in osteoblast differentiation through regulating Ihh/Gli and Wnt signaling pathways. Journal of bone and mineral research. 2011; 25(sup1).
  • Liang G, Yang S*. Collagen XXIV Regulates Osteoblast Differentiation Through Crosstalk of STAT1/Smad7 and TGF‐b/Smad3 Signal Pathways.. J. Bone Mineral Res.. 2011; 24(sup1).
  • Yang S, Chen, W, Chen, L, Li, N, Li, YP. CNBP Conditional Knockout Mice Show Severe Osteoporosis-Like Phenotype. J. Bone Mineral Res.. 2008; 23(Sup 1).
  • Yang S, Li, YP. The Mechanism of RANKL-Evoked [Ca2+]i Oscillations Mediated by RGS10 in Osteoclast Differentiation. J. Bone Mineral Res.. 2007; 22(Sup 1).
  • Yang S, Li, YP. RGS10-Deficient Mice Exhibit Severe Osteopetrosis Due to Impaired Osteoclast Differentiation Associated with Loss of [Ca2+]i Oscillations and NFAT2 Expression. J. Bone Mineral Res.. 2006; 21(Sup 1).
  • Chen, W, Yang S, Abe, Y, Moroi, R, Li, M, Wang, Y, Shao, J, Li, YP. A Mouse Model with Pychodysostosis Phenotype Reveals that Cathepsin K Functions as a Regulator of Osteoclast Apoptosis and Senescence. J. Bone Mineral Res.. 2006; 21(Sup 1).
  • Yang S, Chen, W, Li, YP. Gain and Loss Function Study Reveals that RGS10 Expressed Predominately in Osteoclast is a Critical Mediator in [Ca2+]i Oscillations and Osteoclast Differentiation. J. Bone Mineral Res.. 2005; 20.
  • Yang S, Chen, W, Abe, Y, Li, Y. RGS12 is Essential for Signaling by RANKL for Terminal Differentiation of Osteoclasts via Ca2+ Oscillation Pathway. J. Bone Mineral Res.. 2003; 18.
  • Abe, Y, Chen, W, Yang S, Li, Y. The hHLH Transcription Factor P8 Enhances Bone Formation by Promoting Osteoblast Cell Proliferation and Inhibiting Osteocalcin Expression. J. Bone Mineral Res.. 2003; 18.
  • Franceschi, RT, Yang S, Wei, D, Wang, D, Krebsbach, PH. Combined Gene Therapy with Adenovirus Vectors Expressing the Runx2/Cbfa1 Transcription Factor and Bmp2 Synergistically Stimulates Osteoblast Differentiation and Bone Formation. Gene Therapy. 2002; 5.
  • Yang S, Wang, D, Wei, D, Franceschi, R. Development of a Standardized System for Assessing the Osteogenic Activity of Osteogenic Gene Transduced Mouse Embryonic Fibroblast. J. Bone Mineral Res.. 2001; 16.
  • Wei, D, Yang S, Wang, D, Franceschi, R. Adenovirus-Mediated Expression of Cbfa1/Runx2 in C3H10T1/2 Mesenchymal Cells Induces Mineralization and Expression of Some, But Not All Osteoblast Markers. J. Bone Mineral Res.. 2001; 16.
  • Yang S, Duan, F, Lu, F. Primary Study of Mechaisms of Bystander Effect Caused by Expression of Suicide Gene. Chin J Gastroenter & Hepatol. 1997; 6(4).
See All (13 Total) >
Professional Memberships:
  • membership of AADR/IADR (2011)
  • Board member of Woman committee, International Chinese Hard Tissue Society (2011)
  • American Society for Bone and Mineral Research (2005)
  • Membership for Sigma Xi (2003-2006)
  • American Association for Cell Biology (2003-2005)
  • American Association for Advancement of Science (2003)
  • Board Member of IABMR (2003)
Presentations:
  • Vascularized bone regeneration for critical sized bone defects, BIT’s 6th Annual World Congress of Regenerative Medicine & Stem Cell (2013)
  • Intraflagellar transport in regulation of bone development and homeostasis, Chongqing Medical University (2013)
  • The role of RGS proteins in regulation of bone formation and remodeling, The Oral Microbiome, Immunity & Chronic Disease 50th Anniversary ~ University at Buffalo Oral Biology Graduate Program, UB (2013)
  • Gene and stem cell based vascularized bone regeneration for critical –sized bone defects, invited presentation, University of Georgia (2013)
  • Regulation of bone development and remodeling by RGS proteins and IFT proteins, invited presentation, Campbell Clinic/UTHSC (2013)
  • Gene and stem cell based vascularized bone regeneration for critical –sized bone defects, invited presentation, Henry Ford Hospital (2012)
  • Regulator of G Protein Signaling Protein 12 Regulates the Coupling between Osteoblasts and Osteoclasts during Bone Remodeling, 2012 Annual Meeting of the American Society for Bone Mineral Research, ASBMR (2012)
  • IFT80 Promotes Chondrogenic Differentiation by Regulating Hedgehog and Wnt Signal Pathways, 2012 Annual Meeting of the American Society for Bone Mineral Research., ASBMR (2012)
  • Regulation of bone development and remodeling by RGS proteins, invited presentation, Andel Research Institute (2012)
  • Essential role of Intraflagellar transport 80 in osteoblast differentiation through regulating Ihh/Gli and Wnt signaling pathways., 2011 Annual Meeting of the American Society for Bone Mineral Research. San Diego. (2011)
  • A new fibrillar collagen, Col24α1 regulates osteoblast differentiation and mineralization, 4th New York Skeletal and Medicine Biology Conference (2011)
  • Integration of genetically engineered stem cells and injectable and moldable nano‐calcium sulfate biomaterial for craniofacial bone regeneration, First International Dental and Craniofacial Stem Cell Conference, New York (2011)
  • Collagen XXIV Regulates Osteoblast Differentiation Through Crosstalk of STAT1/Smad7 and TGF‐b/Smad3 Signal Pathways ., 2010 Annual Meeting of the American Society for Bone Mineral Research. (2010)
  • Molecular Regulation of bone formation and resorption, Institute of oral Health Center, UAB School of Dentistry. (2010)
  • Calcium oscillations and bone remodeling, Department of Molecular and Cellular Biology, Roswell Park Cancer Institute (2009)
  • Deletion of RGS12 impairs calcium oscillations and osteoclast differentiation, 2009, Bones and Teeth Gordon Research Conference, University of New England (2009)
  • CNBP Conditional Knockout Mice Show Severe Osteoporosis-Like Phenotype, Thirty Annual Meeting of the American Society for Bone Mineral Research, American Society for Bone Mineral Research (2008)
  • The Mechanism of RANKL Evoked Ca2+] i Oscillations and NFAT2 Expression in Osteoclast Differentiation, Twenty-Ninth Annual Meeting of the American Society for Bone Mineral Research, American Society for Bone Mineral Research (2007)
  • ASBMR Young Investigator Award, Oral Presentation, The Advances in Mineral Metabolism AIMM/ASBMR John Haddad Young Investigators Meeting, The Advances in Mineral Metabolism AIMM/ASBMR John Haddad Young Investigators (2007)
  • RGS10-Deficient Mice Exhibit Severe Osteopetrosis Due to Impaired Osteoclast Differentiation Associated with Loss of [Ca2+] i Oscillations and NFAT2 Expression, Twenty-Eighth Annual Meeting of the American Society for Bone Mineral Research, American Society for Bone Mineral Research (2006)
  • Gain and Loss Function Study Reveals that RGS10 Expressed Predominately in Osteoclast Is a Critical Mediator in [Ca2+] i Oscillations and Osteoclast Differentiation, Twenty-Seventh Annual Meeting of the American Society for Bone Mineral Research, American Society for Bone Mineral Research (2005)
  • RGS12 is Essential for Signaling by RANKL for Terminal Differentiation of Osteoclasts Via Ca2+ Oscillation Pathway, Twenty-Fifth Annual Meeting of the American Society for Bone Mineral Research, American Society for Bone Mineral Research (2003)
  • The hHLH Transcription Factor P8 Enhance Bone Formation by Promoting Osteoblast Cell Proliferation and Inhibiting Osteocalcin Expression, Twenty-Fifth Annual Meeting of the American Society for Bone Mineral Research, American Society for Bone Mineral Research (2003)
  • Combined Gene Therapy with Adenovirus Vectors Expressing the Runx2/Cbfa1 Transcription Factor and Bmp2 Synergistically Stimulates Osteoblast Differentiation and Bone Formation, The American Society of Gene Therapy's 5th Annual Meeting, The American Society of Gene Therapy's (2002)
  • Development of a Standardized System for Assessing the Osteogenic Activity of Osteogenic Gene Transduced Mouse Embryonic Fibroblast, Twenty-Third Annual Meeting of the American Society for Bone and Mineral Research, American Society for Bone and Mineral Research (2001)
  • Adenovirus-Mediated Expression of Cbfal/Runx2 in C3H10T1/2 Mesenchymal Cells Induces Mineralization and Expression of Some, But Not all Osteoblast Markers, Twenty-Third Annual Meeting of the American Society for Bone and Mineral Research, American Society for Bone and Mineral Research (2001)
See All (26 Total) >
Service Activities:
  • School of Dental Medicine Graduate Committee, Thesis, Oral Biology; Advisor (2009)

  • IADR/AADR Fellowships Committee; Board Member (2013-2016)
  • PHD student prelim thesis advisary committee; Advisory Committee (2012)
  • AADRBuffalo Section; Board Member (2012-2015)
  • editorial board; Journal of Investigative Dental Sciences JSM Dentistry ; Editorial Board Member (2012-2014)
  • Cell proliferation editor; Editor (2012)
  • Board member of Woman committee, International Chinese Hard Tissue Society; Board Member (2011-2019)
  • PHD student prelim thesis advisary committee; Advisory Committee (2011-2014)
  • reviewer of Journal of periodontology; Peer Reviewer (2010)
  • Grant reviewers; 2009 - Ad hoc reviewer, Army Medical Research and Material Command (USAMRMC) 2010 - Ad hoc reviewer, Human Frontier Science Program, research grant. 2010 - Ad hoc reviewer, Army Medical Research and Material Command (USAMRMC) 2011 - Ad hoc reviewer, Army Medical Research and Material Command (USAMRMC) 2013 - Ad hoc reviewer, Children’s Tumor Foundation Young Investigator Award (YIA) 2013 - Fellowship reviewer, 2014 IADR/AADR Sjögren"s Syndrome Student Fellowship 2014 - Ad hoc reviewer, Children’s Tumor Foundation Young Investigator Award (YIA) ; Grant Reviewer (2009-2014)
  • PPBS PhD admission committee; Committee Member (2009-2013)
  • Graduate student Research and Honors Committee, Member, University at Buffalo, School of Dental Medicine (2009-2012)
  • Departmental Faculty Recruitment Committee, Member; Member (2009-2014)
  • Laboratory IT in the Forsyth Institute, Boston, MA; Member (2006)
  • journal reviewers; Biomaterials Tissue Engineering Part A Journal of Biomedical Materials Research Part A Journal of Clinical Periodontology Journal of Periodontology International Journal of Biological Science Cell Proliferation Experimental Biology and Medicine Journal of Biomedical Nanotechnology JSM Dentistry PloS One Journal of Cellular Biochemistry Stem Cells and Development Bone ; Ad Hoc Reviewer (2005-2014)
  • Chinese Journal of Gastroenterology and Hepatology; Editor (2003)
  • Laboratory Safety Committee in the Forsyth Institute, Boston, MA; Member (2003-2005)
See All (17 Total) >

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Contact Information

School of Dental Medicine
304 Foster Hall
3435 Main Street
Buffalo, NY 14214
Phone: 716-829-6338
Fax: 716-829-3942
Email: sy47@buffalo.edu


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Yang, Shuying (Sheri) M.D., Ph.D. Assistant Professor, Department of Oral Biology

Address:
B36a Foster Hall
Buffalo, NY 14214
(716)829-6338
sy47@buffalo.edu

Research Profile

Our research focuses on identifying the role and mechanism of novel or known genes in bone-related signal pathways and understanding how these genes regulate craniofacial and bone development and bone remodeling by using gene knockout technology. We are also working on gene therapy and stem cell mediated periodontal and craniofacial bone regeneration.

Identifying the mechanism of craniofacial and bone development and metabolism.

1. The role of mechanism of RGS protein in bone development and metabolism
Most adult skeletal diseases are due to excess osteoclastic activity, leading to an imbalance in bone remodeling which favors resorption. Such diseases would include osteoporosis, periodontal disease, rheumatoid arthritis, multiple myeloma and metastatic cancers. Therefore, understanding the molecular mechanisms of osteoclast and osteoblast differentiation and activation is critical for successful treatment of these diseases. By using a genome-wide screening, RNAi and gene knockout technology, we have identified RGS proteins which are closely related to calcium signaling regulation, and bone development and remodeling. Currently we have generated RGS12 conditional knockout mice, and have analyzed the role and mechanism of this gene in osteoclast differentiation and bone remodeling by conditionally deleting this gene in osteoclast specific knockout model and inducible knockout model.

2. The role and mechanism of IFT/Cilia in skeleton and craniofacial development and bone remodeling. Primary cilia/IFT proteins are important factors for the etiology of skeletal and craniofacial disorders, The mutation of different IFT/cilia proteins causes the loss or severe reduction of cilia known as the ciliopathies, and often has skeletal and craniofacial defect phenotypes. However, the function and mechanism of cilia/IFT proteins in cilia formation, skeletal and craniofacial development and bone homeostasis is largely unknown. Thus, we are interested in revealing the function and regulatory mechanism of IFT/cilia proteins in skeletal and craniofacial development, bone homeostasis, and bone healing. Currently, we have investigated the role and mechanism of two IFT proteins-IFT20 and IFT80 in osteoblast and chondrocyte differentiation and activation by performing RNAi silence and gene overexpression in vitro. We have generated IFT80 conditional knockout mice and are analyzing the role and mechanism of IFT proteins in bone development and remodeling.

Genetic engineered stem cells mediated bone tissue engineering

Bone fractures and destruction result in more than 1.3 million surgical procedures each year in the United States alone. In 2004, musculoskeletal conditions cost the U. S. $849 billion, 7.7% of the national gross domestic product. Current surgical techniques use autogenous, allogeneic and prosthetic materials, and the most commonly used and the gold standard for bone regeneration is autologous grafting. However, autografts are often challenging in cases where extensive grafting is needed, but large volumes of autogenous bone are not available. Prosthetic materials avoid these issues, but their effectiveness is limited by unpredictable graft resorption, infection, structural failure and unsatisfactory aesthetic outcomes. In addition, tissue regeneration may only occur in the outer perimeter of graft structures due to the lack of stable vascularization. Hence, the ability to generate new bone graft substitutes for accelerating neovascularization and bone regeneration is a major clinical need. However, to date, vascularized mechanically competent osteoconductive/inductive constructs have not been documented. A major barrier to breakthroughs in this field is the lack of sufficient integration of biomaterial design and engineered cells, such as stem cells, to promote angiogenesis and bone regeneration. Therefore, we are focusing on develop novel genetically modified stem cell mediated angiogenesis and bone regeneration. We have developed an injectable and molding nano calcium sulfate delivery system and multi-stem cells co-culture system for facilitating vascularized bone regeneration in vivo bone defect models.


Representative Publications Search Publications in MEDLINE

* Corresponding author
1. Keinan D, Yang S*, Cohen R, Yuan X, Liu T, Li YP. (2014) Role of regulator of G protein signaling proteins in bone. Front Biosci (Landmark Ed). Jan 1;19:634-48.
2. Liu J, Mao K, Liu Z, Guo W, Wang X, Cui F, Mao K*, Yang S*. (2013) Injectable biocomposites for bone healing in rabbit femoral condyle defects. PLoS One. Oct 16;8(10):e75668. doi: 10.1371/journal.pone.0075668.
3. He X, Dziak R, Yuan X, Genco R, Swithart M, Li C, Yang S*. (2013) BMP2 genetically engineered MSCs and EPCs promote vascularized bone regeneration in rat critical-sized calvarial bone defects. PloS One. 8(4):e60473. doi: 10.1371/journal.pone.0060473. Epub 2013 Apr 2. PMID:23565253
4. Yang S*, Li YP, Liu T, He X, Yuan X, Li C, Cao J, Kim Y. (2013) Mx1-Cre mediated Rgs12 conditional knockout mice exhibit increased bone mass phenotype. Genesis. 2013 Mar;51(3):201-9. doi: 10.1002/dvg.22373. Epub 2013 Feb 25. PMID: 23349096.
5. Wang C, Yuan X, Yang S*. (2013) IFT80 is essential for chondrocyte differentiation by regulating Hedgehog and Wnt signaling pathways. Exp Cell Res. Exp Cell Res. 2013 Mar 10;319(5):623-32. doi: 10.1016/j.yexcr.2012.12.028. Epub 2013 Jan 16. PMID:
23333501
6. He X, Dziak R, Mao K, Genco R, Swithart M, Li C, Yang S*. (2013) Integration of a novel injectable nano calcium sulfate/alginate scaffold and BMP2 gene-modified mesenchymal stem cells for bone regeneration. Tissue Eng Part A. Feb;19(3-4):508-18. PubMed PMID: 22994418; PubMed Central PMCID: PMC3542881.
7. Wang W, Olson D, Liang G, Franceschi RT, Li C, Wang B, Wang SS, Yang S*.(2012) Collagen XXIV (Col24α1) promotes osteoblastic differentiation and mineralization through TGF-β/Smads signaling pathway. Int J Biol Sci. 8(10):1310-22. PubMed PMID: 23139630; PubMed Central PMCID: PMC3492790.
http://dx.doi.org/10.7150/ijbs.5136.
8. Yang S*, Wang C. (2012) The intraflagellar transport protein IFT80 is required for cilia formation and osteogenesis. Bone. Sep;51(3):407-17. PubMed PMID: 22771375; PubMed Central PMCID: PMC3412883.
9. Dicesare P, Fox WM, Hill MJ, Krishnan GR, Yang S, Sarkar D. (2012) Cell-material interactions on biphasic polyurethane matrix. J Biomed Mater Res A. Dec 18. doi: 10.1002/jbm.a.34515. [Epub ahead of print] PubMed PMID: 23255285.
http://dx.doi.org/10.1002/jbm.a.34515.
10. Patel M and Yang S*. (2010) Advances in reprogramming somatic cells to induced pluripotent stem cell, Stem Cell Reviews and Reports. Sep;6(3):367-80.
11. Soltanoff CS, Yang S, Chen W, Li YP. (2009) Signaling networks that control the lineage commitment and differentiation of bone cells Crit Rev Eukaryot Gene Expr. 19(1). 1-46. PMID:19191755 PMCID:PMC3392028.
12. Yang S, Chen, W, Stashenko P, Li Y-P. (2007) RGS10A is a Critical Component in the RANKL-Evoked Signaling Pathway for Osteoclast Differentiation Journal of Cell Science. 120(Pt19). 3362-3371.
13. Yang S, Li YP. (2007) RGS10 null mutation impairs osteoclast differentiation resulting from the loss of [Ca2+]i oscillation regulation. Genes & Development. 21(14). 1803-1816.
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