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 About Oral BiologyNew Home     August 29, 2014  

Mine Tezal  PhD, DDS

Department of Oral Biology

Assistant Professor

Specialty/Research Focus

Community Dentistry; Periodontics

Faculty Research Profile

 
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Education and Training:
  • Cert, NIH/NCI (2007)
  • Fellowship, Oral Biology, State University of New York at Buffalo (2006)
  • Cert, Periodontology, State University of New York at Buffalo (2004)
  • PhD, Epidemiology and Community Health, State University of New York at Buffalo (2004)
  • MS, State University of New York at Buffalo (1998)
  • DDS, University of Istanbul (1990)
Employment:
  • Assistant Professor, Oral Diagnostic Sciences, Oral Diagnostic Sciences, State University of New York at Buffalo (2007-present)
  • Research Assistant Professor, Social and Preventive Medicine, Social and Preventive Medicine, State University of New York at Buffalo (2007-present)
  • Research Assistant Professor, Oral Biology, Oral Biology, State University of New York at Buffalo (2004-present)
  • Research Scientist, Epidemiology, Dental and Maxillofacial Prosthetics, Roswell Park Cancer Institute (2006-2009)
  • Post Doctoral Fellow, Oral Biology, Oral Biology, State University of New York at Buffalo (2003-2006)
  • Research Scientist, Oral Biology, Oral Biology, State University of New York at Buffalo (1997-2003)
  • Clinical Instructor, Periodontics And Endodontics, Periodontics and Endodontics, State University of New York at Buffalo (1996-2000)
  • Graduate Research Assistant, Oral Biology, Oral Biology, State University of New York at Buffalo (1992-1996)
  • Private Practice (1990-1992)
  • Faculte de Chirurgie Dentaire de Paris 7 (1990)
Awards and Honors:
  • AADR Neal W. Chilton Fellowship in Clinical Research (2011)
  • NIDCR Post-Doctoral Training Grant Fellow (2003)
  • NIDCR Dentist Scientist Award (1997)

Research Expertise:
  • Periodontology: -Certificate Periodontology, School of Dental Medicine, SUNY at Buffalo, 2004. -Post-doc Oral Biology, School of Dental Medicine, SUNY at Buffalo 2004 . -Research Scientist, Periodontal Disease Research Center, Oral Biology, SUNY at Buffalo, 1997-2002
  • Oral Epidemiology: -Ph.D. in Epidemiology and Community Health, School of Medicine and Biomedical Sciences, SUNY at Buffalo, 2004. -Topics in Clinical Trials Management, Johns Hopkins Bloomberg School of Public Health. Baltimore, MD, 2011 -Conducting Epidemiologic Research, Johns Hopkins Bloomberg School of Public Health. Baltimore, MD, 2011. -IADR Satellite Symposium Task Force on Design and Analysis in Oral Health Research, Introduction to Clinical Research. San Diego, CA, 2011. -NYAS Integrating Student Research into the Medical School Curriculum, New York, NY, 2012. -Bioinformatics and Technology Applications in Medication Management, UB Center of Excellence in Bioinformatics and Life Sciences, Buffalo, NY, 2008. -Introduction to Biomedical Ontologies. State University of New York at Buffalo, NY, 2008.
  • Human Papilloma Virus
  • Smoking
  • Osteonecrosis of the jaw from Bisphosphonates
Grants and Sponsored Research:
  • July 2006-June 2009
    Periodontal Disease and the Incidence of Oral Cancer (1R03CA119262-01A1)
    NIH/NCI
    Role: Principal Investigator
    $100,000.00

Journal Articles:
See All (16 Total) >

Abstracts:
  • Tezal M, Wactawski-Wende J, Stoler, Daniel L, Scannapieco FA. Tumor HPV Status and Stage in Head and Neck Cancers. J Dent Res. 2012.
  • Tezal M, Wactawski-Wende J, Sullivan M, Hyland, Andrew, Stoler, Daniel L, Marshall JR, Reid, Mary, Rigual, Nestor R, Loree, Thom, Yilmaz, Ozlem, Scannapieco FA. Protective Potential of Lactic-Acid Bacteria in Head and Neck Cancers. J Dent Res. 2011.
  • Tezal M, Sullivan MA, Stoler D, Rigual NR, Wactawski-Wende J, and Scannapieco FA.. Periodontitis Predicts Human Papillomavirus Status in Head and Neck Cancers. J Dent Res. 2010.
  • Tezal M, Sullivan M, Scannapieco FA, Marshall JR, Reid M, Hyland, A, Loree T, Rigual NR, Wactawski-Wende J, Stoler, D. Chronic Inflammation Predicts HPV Status of Head and Neck cancers. J Dent Res. 2010.
  • Tezal M, Sullivan MA, Hyland A, Marshall JR, Stoler D, Reid ME, Loree T , Rigual NR, Merzianu M, Hauck L, Lillis C, Wactawski-Wende J, Scannapieco FA.. Chronic Periodontitis and the Incidence of Head and Neck Squamous Cell Carcinoma. J Dent Res. 2009.
  • Tezal M, Sullivan MA, Stoler D, Hyland A, Melendy TE, Smaldino PJ, Rigual N, Loree T. Chronic Periodontitis, Smoking and Human Papillomavirus 16 Interaction in Base of Tongue Cancers. Arch Otolaryngol Head Neck Surg. 2008.
  • Tezal M, Sullivan MA, Hyland A, Loree T, Rigual A, Stoler D. Chronic periodontitis-human papillomavirus synergy in base of tongue cancers. J Dent Res. 2008.
  • Tezal M, Sullivan M, Reid ME, Marshall JR, Loree TR, Hyland AJ, Stoler D, Scannapieco F. Smoking: A Modifier for Inflammation-Oral Cancer Association. Oral Oncol. 2007.
  • Tezal M, Sullivan M, Reid ME, Marshall JR, Hyland A, Stoler D, Scannapieco FA. Periodontitis, Smoking and Alcohol Use in Oral Cancer Risk. J Dent Res. 2007; 86(A).
  • Tezal M, Sullivan M, Reid ME, Marshall JR, Hausmann E, Hyland A, Wactawski-Wende J, Loree TR, Rigual N, Scannapieco FA. Chronic Periodontitis and the Risk of Oral Cancer: Preliminary Findings. Arch Otolaryngol Head Neck Surg. 2006.
  • Tezal M, Grossi S, Scannapieco FA, Genco RJ. Capnocytophaga Species and Eubacterium Saburreum shift roles with increasing plaque.. J Dent Res. 2004.
  • Tezal M, Grossi S, Ho AW, Genco RJ. Is Periodontal Disease related to oral neoplasm?. J Dent Res. 2003.
  • Tezal M, Grossi S, Ho AW, Dunford R, Genco RJ. The effect of alcohol consumption on severity of periodontal disease. J Dent Res. 1999.
  • Wactawski-Wende J, Grossi S, Trevisan M, Genco RJ, Dunford R, Ho AW, Altekin M, Hausmann E, Hreshchyshyn M. The relationship between osteopenia and periodontitis in post-menopausal women. Am J Epidemiol. 1995; 141(11).
  • Altekin M, Wactawski-Wende J, Grossi S, Trevisan M, Hreshchyshyn MM, Dunford R, Genco RJ. The relationship between bone density and periodontal disease. J Dent Res. 1995.
See All (15 Total) >
Books and Book Chapters:
  • Tezal M, Sullivan M. Chronic periodontitis and the risk of oral cancer. In:Progress in Oral Cancer Research. Nova Science Publishers, Inc.. 2008.
  • Tezal M. Tobacco Use, Inflammation, Oral HPV Infection and Changing Epidemiology of Head and Neck Cancers. iConcept Press Ltd.. 1900.
Professional Memberships:
  • New York Academy of Sciences (2007)
  • American Association for Dental Research (1995)
  • American Dental Association (1995)
  • American Academy of Periodontology/Journal of Periodontology (1995)
  • International Association for Dental Research (1995)
Presentations:
  • Tumor HPV Status and Stage in Head and Neck Cancers, International Association for Dental Research, IADR (2012)
  • Protective Potential of Lactic-Acid Bacteria in Head and Neck Cancers, International Association for Dental Research (2011)
  • Periodontitis Predicts Human Papillomavirus Status in Head and Neck Cancers, The 88th IADR General Session & Exhibition, International Association for Dental Research (2010)
  • Chronic Inflammation-HPV-Tobacco Interactions in Head and Neck Cancers, Biotechnology and Information Technology Life Sciences' 2nd Annual Congress and Expo of Molecular Diagnostics, Biotechnology and Information Technology Life Sciences (2009)
  • Chronic Periodontitis and the Incidence of Head and Neck Squamous Cell Carcinoma, The American Academy of Periodontology 95th Annual Meeting, American Academy of Periodontology (2009)
  • Interactions Affecting Oral Cancer Risk, Practical Oral Medicine Applications. UB Department of Oral Diagnostic Sciences Anniversary Celebration, University at Buffalo (2009)
  • Chronic Periodontitis, Smoking and Human Papillomavirus 16 Interaction in Base of Tongue Cancers, The 7th International Conference on Head and Neck Cancer, AHNS (2008)
  • Chronic Periodontitis, Smoking and Human Papillomavirus 16 Interaction in Base of Tongue Cancers., American Head and Neck Society (2008)
  • Smoking-Periodontitis Interaction for Tumor HPV Status, Dental and Maxillofacial Prosthetics, Roswell Park Cancer Institute (2008)
  • Chronic Periodontitis, Smoking and Human Papillomavirus in Oropharyngeal Cancers, Oral Biology, School of Dental Medicine (2008)
  • Chronic Periodontitis, HPV and Smoking in Head and Neck Cancers, Social and Preventive Medicine, School of Medicine and Biomedical Sciences (2008)
  • Chronic Periodontitis-Human Papillomavirus Synergy in Base of Tongue Cancers, American Association for Dental Research (2008)
  • Smoking: A Modifier for Inflammation-Oral Cancer Association, The 1st World Congress of the International Academy of Oral Oncology (2007)
  • Periodontitis, Smoking and Alcohol Use in Oral Cancer Risk, International Association for Dental Research, IADR (2007)
  • Chronic Periodontitis and the Risk of Oral Cancer, Periodontology/Prevention/Geriatrics, University of Michigan,, University of Michigan (2007)
  • Chronic Periodontitis and the Risk of Oral Cancer, Periodontics, University of Texas, University of Texas (2007)
  • Chronic Periodontitis and the Risk of Oral Cancer, Periodontology, University of Connecticut Health Center, University of Connecticut Health Center (2007)
  • Chronic Periodontitis and the Risk of Oral Cancer: Preliminary Findings, The American Head and Neck Society Annual Meeting & Research Workshop on the Biology, Prevention and Treatment of Head and Neck Cancer, The American Head and Neck Society (2006)
  • Chronic Periodontitis and Base of Tongue Cancer, RPCI Disease Site Research Group (DSRG), Roswell Park Cancer Institute (2006)
  • Chronic Periodontitis and Base of Tongue Cancer, RPCI Head and Neck/Dental Research Group, Roswell Park Cancer Institute (2006)
  • Chronic Periodontitis and the Risk of Oral Cancer, Head and Neck Surgery, Roswell Park Cancer Institute (2005)
  • Capnocytophaga Species and Eubacterium Saburreum Shift Roles with Increasing Plaque, The 8th International Symposium on Periodontics and Restorative Dentistry/The International Quintessence Publishing Group and American Academy of Periodontology, The International Quintessence Publishing Group and American Academy of Periodontology (2004)
  • Is Periodontal Disease Related to Oral Neoplasm?, American Association for Dental Research (2003)
  • The Effect of Alcohol Consumption on Severity of Periodontal Disease, International Association for Dental Research, IADR (1999)
  • The Relationship Between Osteopenia and Periodontitis in Post-menopausal Women, American Association of Epidemiology (1995)
  • The Relationship between Bone Density and Periodontal disease., American Association for Dental Research, AADR (1995)
See All (26 Total) >
Service Activities:
  • Faculty Senate Executive Committee; Member (2011)

  • IADR/AADR Evidence-Based Dentistry Network; Treasurer (2012)
  • AADR Buffalo Section; Treasurer (2012)
  • UB Faculty Senate Executive Committee; Member (2011)
  • IADR/AADR Network for Practice-Based Research Scientific Group; Member (2011)
  • CE Cafe‘...Distance Learning Lecture Series Continuing Dental Education; Presentor (2010)
  • Faculty Senate; Member (2010)
  • AADR Buffalo Section; Secretary (2010)
  • The School of Dental Medicine "Free Prophy Day"; Contributor (2010-2010)
  • Harvest House Women‘s Ministry; Volunteer (2009)
  • The Sixth Annual Hispanic Health Fair; Oral cancer, caries and periodontal disease screening.; Contributor (2009-2009)
  • UB Oral Diagnostic Sciences Dept Anniversary CDE Program; Contributor (2009-2009)
  • IADR/AADR Behavioral, Epidemiologic and Health Services Research Scientific Group; Member (2009)
  • IADR/AADR Women in Science; Member (2009)
  • IADR/AADR Evidence-Based Dentistry Network; Member (2009)
  • Student Research and Honors Committee; Member (2008)
  • Journal of Women's Health; Peer Reviewer (2008)
  • Faculty Awards Committee; Member (2007-2009)
  • Student Research Day, School of Dental Medicine; Judge; Judge (2007)
  • Central European Journal of Medicine; Peer Reviewer (2007)
  • Journal of Periodontology; Peer Reviewer (1997)
See All (21 Total) >

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Contact Information

355 Squire Hall
Buffalo, NY 14214
Phone: 716 829 2241
Fax: 716 829 3554
Email: mtezal@buffalo.edu


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Tezal, Mine DDS, PhD Clinical Assistant Professor, Department of Oral Biology

Address:
202 Foster Hall
Buffalo, NY 14214
(716)829-2154
mtezal@buffalo.edu

Faculty Profile

A steady increase in the incidence of oropharyngeal cancers has been observed over the last three decades despite a significant decline in tobacco consumption during the same period. This increase has been mainly attributed to oral infection with human papillomavirus (HPV) type 16. A highly effective vaccine is available to prevent cervical HPV infection, which is recommended for females aged 9 to 26 years and males aged 9 to 21 years prior to potential exposure. However, oral HPV infection can be transmitted at or any time after birth. Oral HPV DNA has been found in 4%-87% of newborns and children age 3-11 years, albeit with low levels of transcription suggesting that is a transient event. Therefore, the vaccine has no protective effect in the large percentage of the population that has already been exposed to the virus. Identifying factors associated not only with the acquisition but also with the persistence of the virus will improve both prevention and treatment of HPV-related diseases, benefiting also those who are already infected.

Our studies have demonstrated that periodontitis, a chronic inflammatory disease, was associated with increased risk of oral potentially malignant disorders and head and neck squamous cell carcinoma (HNSCC). A history of periodontitis also predicted poorly differentiated tumor status in the oral cavity. These associations remained statistically and clinically significant in never smokers and never drinkers. In addition, a history of periodontitis was a significant predictor of the tumor HPV-16 status among patients with oral cavity, oropharyngeal and laryngeal cancer patients. Presently, we are investigating the role of dental caries on HNSCC, and the potential interaction between periodontitis and dental caries. In addition, epidemiologic studies assessing the role of local inflammation on oral HPV infection in healthy young population are underway.

Representative Publications Search Publications in MEDLINE

Tezal M, Scannapieco FA, Wactawski-Wende J, Hyland A, Marshall JR, Rigual NR, Stoler DL. Local inflammation and human papillomavirus status of head and neck cancers. Arch Otolaryngol Head Neck Surg 2012;138(7):669-75. PMID: 22710409.

Tezal M. Interaction between chronic inflammation and oral HPV infection in the etiology of head and neck cancers. Int J Otolaryngol. 2012;2012:575242. Epub 2012 Feb 23. PMID: 22518158.

Tezal M, Uribe S. A lack of consensus in the measurement methods for and definition of periodontitis. J Am Dent Assoc 2011;142(6):666-7. PMID: 21628689.

Tezal M, Sullivan MA, Marshall JR. The role of chronic periodontitis in prevention and treatment of head and neck cancers. Current Cancer Therapy Reviews 2010;6(4):323-33.

Tezal M, Sullivan MA, Hyland A, Marshall JR, Stoler D, Reid ME, Loree T Rigual NR, Merzianu M, Hauck L, Lillis C, Wactawski-Wende J, Scannapieco FA. Chronic Periodontitis and the incidence of head and neck squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev 2009;18(9):2406-12. PMID: 19745222.

Tezal M, Sullivan MA, Stoler D, Hyland A, Melendy T, Smaldino PJ, Rigual N, Loree T. Chronic peridontitis-human papillomavirus synergy in base of tongue cancers. Arch Otolaryngol Head Neck Surg 2009;135(4):391-6. PMID: 19380363.

Tezal M, Sullivan MA, Reid ME, Marshall JR, Hyland A, Loree T, Lillis C, Hauck L, Wactawski-Wende J, and Scannapieco FA. Chronic Periodontitis and the Risk of Tongue Cancer. Arch Otolaryngol Head Neck Surg 2007;133(5):450-4. PMID: 17515503.

Tezal M, Scannapieco FA, Wactawski-Wende J, Grossi SG, Genco RJ. Supragingival plaque may modify the effects of subgingival bacteria on attachment loss. J Periodontol 2006;77(5):808-13. PMID: 16671872.

Tezal M, Wactawski-Wende JW, Grossi SG, Dmochowski J, Genco RJ. Periodontal disease and the incidence of tooth loss in postmenopausal women. J Periodontol 2005;76(7):1123-8. PMID: 16018755.

Tezal M, Grossi SG, Genco RJ. Is periodontitis associated with oral neoplasms? J Periodontol 2005;76(3):406-10. PMID: 15857075.

Tezal M, Grossi SG, Ho AW, Genco RJ. Alcohol consumption and periodontal disease. The Third National Health and Nutrition Examination Survey. J Clin Periodontol. 2004;31(7):484-8. PMID: 15191580.

Tezal M, Grossi SG, Ho AW, Genco RJ. The effect of alcohol consumption on periodontal disease. J Periodontol 2001;72(2):183-9. PMID: 11288791.

Tezal M, Wactawski-Wende J, Grossi SG, Ho AW, Dunford R, Genco RJ. The relationship between bone mineral density and periodontitis in postmenopausal women. J Periodontol 2000;71(9):1492-8. PMID: 11022780.

Wactawski-Wende J, Grossi SG, Trevisan M, Genco RJ, Tezal M, Dunford RG, Ho AW, Hausmann E, Hreshchyshyn MM. The role of osteopenia in oral bone loss and periodontal disease. J Periodontol 1996 67(10 Suppl):1076-84. PMID: 8910826.