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 About Oral BiologyNew Home     July 30, 2016  

Jason Kay  PhD

Department of Oral Biology

Assistant Professor

Faculty Research Profile

 
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Education and Training:
  • Postdoctoral Fellow, Hospital for Sick Children (2013)
  • Postdoctoral Fellow, University of Queensland (2008)
  • PhD, Molecular Cell Biology, University of Queensland (2007)
  • MS, Molecular Microbiology, University of Calgary (2000)
  • BS, Biochemistry, University of Calgary (1998)
Employment:
  • Assistant Professor, Oral Biology, University at Buffalo (2013-present)
Awards and Honors:
  • Dean's Commendation (2008)
  • Keystone Macrophage conference travel award (2007)
  • ASMR Queensland Award for Health and Medical Research (Finalist) (2006)

Research Expertise:
  • Cell Biology
  • Immunology
  • pathogen-host interactions
  • Phagocytosis

Journal Articles:
See All (22 Total) >

Professional Memberships:
  • Society for Leukocyte Biology (2014)
  • American Association for Dental Research (2013)
  • International Association for Dental Research (2013)
  • American Society for Cell Biology (2008)
Presentations:
  • Evasion of Phagosomal Destruction by S. gordonii, Buffalo Immunology Conference, The Witebsky Center for Microbial Pathogenesis and Immunology (2015)
  • Cholesterol dictates the subcellular distribution of phosphatidylserine, Lysosomes and Endocytosis, Gordon Research Conferences (2014)
  • mTOR is Required for Lysosome Tubulation and MHCII Trafficking in Macrophages and Dendritic Cells, Lysosomes and Endocytosis, Gordon Research Conferences (2014)
  • Role of lipids and lysosomes in innate immunity; insights from advanced live imaging of macrophages, Invited Speaker, University of Louiseville (2013)
  • Role of lipids and lysosomes in innate immunity; insights from advanced live imaging of macrophages, Invited speaker, University of Alberta (2012)
  • Role of lipids and lysosomes in innate immunity; insights from advanced live imaging of macrophages, Invited speaker, University at Buffalo (2012)
  • Characterization of Phosphatidylserine Dynamics in Membranes of Live Cells, Gordon Research Conference - Lysosomes and Endocytosis, Gordon Research Conferences (2012)
  • The Role of Arl8b and Rab7 GTPases in Lysosome Tubulation, American Society for Cell Biology Annual Meeting (2011)
  • Phosphatidylserine Dynamics in Cellular Membranes, Gordon Research Conference - Molecular and Cellular Biology of Lipids (2011)
  • A Diffusional Barrier in the Phagocytic Cup, American Society for Cell Biology Annual Meeting, American Society for Cell Biology (2009)
  • Dual Roles for the Recycling Endosome in Phagocytosis, Gordon Research Conference - Lysosomes and Endocytosis (2008)
  • Imaging Cytokine Secretion in Macrophages: Imaging to demonstrate subdomains of the recycling endosome, Hunter Cellular Biology Meeting (2008)
  • Protein Kinase A in the Regulation of Macrophage Apolipotprotein E Trafficking and Secretion, Hunter Cellular Biology Meeting (2008)
  • Modification of the Phagocytic Cup by Lipid Rafts, Keystone Macrophage conference (2007)
  • Differential Requirement for Recycling Endosome in Phagocytosis and Cytokine Secretion, Australasian Society for Immunology 37th Annual Scientific Meeting (2007)
  • Lipid Raft Dependence of Cytokine Secretion and Phagocytosis in Macrophages, Australian Society for Biochemistry and Molecular Biology ComBio (2006)
  • Cytokine Secretion, Phagocytosis and Cholesterol, Queensland Premier Awards for Health and Medical Research (2006)
  • Caveolin in the Hippocampus and its Interaction with SNAREs, Society for Neuroscience 32nd Annual Meeting, Society for Neuroscience (2002)
  • Molecular basis of the modulation of calcium channel function by cysteine string protein, Society for Neuroscience 32nd annual Meeting (2002)
  • Distinct modes of action by the J domain and the cysteine string domain of CSP modulate G protein function, Society for Neuroscience 32nd annual Meeting (2002)
  • Caveolin in the Hippocampus and its Interaction with SNAREs, Alberta Neuroscience Conference (2002)
  • Soil Microbial Community Responses to Incubation in C5+ Followed by DCPD, Canadian Society of Microbiology Annual Meeting (2000)
  • Biodegradation of C5+ Hydrocarbon Compounds by Aerobic and Anaerobic Communities Enriched from Pyrolysis Plant Soils, Canadian Society of Microbiology Annual Meeting (2000)
  • Characterisation of C5+ Degrading Microbial Communities from Soil, Canadian Society of Microbiology Annual Meeting (1999)
See All (24 Total) >
Service Activities:
  • School of Dental Medicine Admissions Committee; Member (2015)
  • School of Dental Medicine Graduate Committee, D.D.S./Ph.D., Oral Biology; Member (2015)
  • School of Dental Medicine Ad Hoc Committee; Member (2015)
  • School of Dental Medicine Graduate Committee, Preliminary Exams, Oral Biology; Member (2015-2015)
  • School of Dental Medicine Graduate Committee, Preliminary Exams, Oral Biology; Member (2015-2015)
  • School of Dental Medicine Graduate Committee, D.D.S./Ph.D., Oral Biology; Member (2014)
  • School of Dental Medicine Student Research and Honors Committee; Member (2014)
  • School of Dental Medicine Graduate Committee, Preliminary Exams, Oral Biology; Member (2013-2014)

  • AADR Buffalo Section; Treasurer (2015)
  • Society for Leukocyte Biology - Membership committee; Member (2015)
  • External Thesis Examiner; Thesis examiner for Xiaying Qi, University of Queensland; Examiner (2015-2015)
  • AADR Buffalo Section; Secretary (2014-2015)
See All (12 Total) >

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Contact Information

B10A Foster Hall
3435 Main Street
Buffalo, NY 14214
Phone: 716 829 2073
Fax: 716 829 2387
Email: jasonkay@buffalo.edu


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Kay, Jason G. M.Sc., Ph.D. Assistant Professor, Department of Oral Biology

Address:
B10a Foster Hall
Buffalo, NY 14214
(716)829-2073
jasonkay@buffalo.edu

Research Profile


My lab's focus is on understanding the cell biology of macrophages and dendritic cells in the context of the oral environment to increase our understanding of the roles these cells play in both oral cavity immune homeostasis and disease development. We focus on phagocytosis, the process whereby invading microorganisms are taken up by immune cells and destroyed.

A main area of investigation in the lab is looking to understand how normally commensal (healthy) bacteria (ie Streptococcus spp.) can avoid being killed when they’re in the phagosome, leading to increased destruction during oral diseases such as periodontitis or the development of extra-oral infections such as endocarditis. Understanding the mechanisms behind this survival, as well as how changes in the local environment can alter the microbial survival, will lead us to better treatments of such conditions.

We are also investigating the process of phagocytosis itself, looking to understand the role various proteins and lipids have in the normal maturation of the phagosome. With such knowledge we hope to gain an understanding of how to correct the phagocytic process when problems arise, such as when pathogens interfere with the process to allow for their own survival.