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 About Oral BiologyNew Home     August 1, 2014  

Jason Kay  PhD

Department of Oral Biology

Assistant Professor

Faculty Research Profile

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Education and Training:
  • Postdoctoral Fellow, Hospital for Sick Children (2013)
  • Postdoctoral Fellow, University of Queensland (2008)
  • PhD, Molecular Cell Biology, University of Queensland (2007)
  • MS, Molecular Microbiology, University of Calgary (2000)
  • BS, Biochemistry, University of Calgary (1998)
  • Assistant Professor, Oral Biology, University at Buffalo (2013-present)
Awards and Honors:
  • Dean's Commendation (2008)
  • Keystone Macrophage conference travel award (2007)
  • ASMR Queensland Award for Health and Medical Research (Finalist) (2006)

Journal Articles:
See All (20 Total) >

Professional Memberships:
  • International Association for Dental Research (2013)
  • American Society for Cell Biology (2008)
  • Characterization of Phosphatidylserine Dynamics in Membranes of Live Cells, Gordon Research Conference - Lysosomes and Endocytosis (2012)
  • The Role of Arl8b and Rab7 GTPases in Lysosome Tubulation, American Society for Cell Biology Annual Meeting (2011)
  • Phosphatidylserine Dynamics in Cellular Membranes, Gordon Research Conference - Molecular and Cellular Biology of Lipids (2011)
  • A Diffusional Barrier in the Phagocytic Cup, American Society for Cell Biology Annual Meeting, American Society for Cell Biology (2009)
  • Dual Roles for the Recycling Endosome in Phagocytosis, Gordon Research Conference - Lysosomes and Endocytosis (2008)
  • Imaging Cytokine Secretion in Macrophages: Imaging to demonstrate subdomains of the recycling endosome, Hunter Cellular Biology Meeting (2008)
  • Protein Kinase A in the Regulation of Macrophage Apolipotprotein E Trafficking and Secretion, Hunter Cellular Biology Meeting (2008)
  • Modification of the Phagocytic Cup by Lipid Rafts, Keystone Macrophage conference (2007)
  • Differential Requirement for Recycling Endosome in Phagocytosis and Cytokine Secretion, Australasian Society for Immunology 37th Annual Scientific Meeting (2007)
  • Lipid Raft Dependence of Cytokine Secretion and Phagocytosis in Macrophages, Australian Society for Biochemistry and Molecular Biology ComBio (2006)
  • Cytokine Secretion, Phagocytosis and Cholesterol, Queensland Premier Awards for Health and Medical Research (2006)
  • Caveolin in the Hippocampus and its Interaction with SNAREs, Society for Neuroscience 32nd Annual Meeting, Society for Neuroscience (2002)
  • Molecular basis of the modulation of calcium channel function by cysteine string protein, Society for Neuroscience 32nd annual Meeting (2002)
  • Distinct modes of action by the J domain and the cysteine string domain of CSP modulate G protein function, Society for Neuroscience 32nd annual Meeting (2002)
  • Caveolin in the Hippocampus and its Interaction with SNAREs, Alberta Neuroscience Conference (2002)
  • Soil Microbial Community Responses to Incubation in C5+ Followed by DCPD, Canadian Society of Microbiology Annual Meeting (2000)
  • Biodegradation of C5+ Hydrocarbon Compounds by Aerobic and Anaerobic Communities Enriched from Pyrolysis Plant Soils, Canadian Society of Microbiology Annual Meeting (2000)
  • Characterisation of C5+ Degrading Microbial Communities from Soil, Canadian Society of Microbiology Annual Meeting (1999)
See All (18 Total) >
Service Activities:

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Contact Information

B10A Foster Hall
3435 Main Street
Buffalo, NY 14214
Phone: 716 829 2073
Fax: 716 829 2387

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Kay, Jason G. MSc, PhD Assistant Professor, Department of Oral Biology

B10a Foster Hall
Buffalo, NY 14214

Faculty Profile


1998 BSc (Biochemistry) University of Calgary, Calgary, AB, Canada
1998-2000 MSc (Molecular Microbiology) University of Calgary, Calgary, AB, Canada (Mentor: Gerrit Voordouw, PhD)
2003-2007 PhD (Molecular Cell Biology) University of Queensland, Brisbane, QLD, Australia (Mentor: Jennifer Stow, PhD)
2008-2013 Postdoctoral Fellow (Cell Biology) Hospital for Sick Children, Toronto, ON, Canada (Mentor: Sergio Grinstein, PhD)

Representative Publications Search Publications in MEDLINE

Kay, J.G. and S. Grinstein. Phosphatidylserine-Mediated Cellular Signaling. 2013. Adv Exp Med Biol 991:177-193

Mrakovic, A., J.G. Kay, W. Furuya, J.H. Brumell and R.J. Botelho. 2012. Rab7 and Arl8 GTPases are Necessary for Lysosomal Tubulation in Macrophages. Traffic 13:1667-1679

Kay, J.G., M. Koivusalo, X. Ma, T. Wohland and S. Grinstein. 2012. Phosphatidylserine Dynamics in Cellular Membranes. Mol Biol Cell 23(11):2198-2212.

Golebiewska U., J.G. Kay, T. Masters, S. Grinstein, W. Im, R.W. Pastor, S. Scarlata and S. McLaughlin. 2011. Evidence for a Fence that Impedes the Diffusion of Phosphatidylinositol 4,5-bisphosphate out of the Forming Phagosomes of Macrophages. Mol Biol Cell 22(18):3498–3507.

Wykes, M.N., J.G. Kay, A. Manderson, X.Q. Liu, D.L. Brown, D.J. Richard, J. Wipasa, S.H. Jiang, M.K. Jones, C.J. Janse, A.P. Waters, S.K. Pierce, L.H. Miller, J.L. Stow and M.F. Good. 2011. Rodent Blood-Stage Plasmodium Survive in Dendritic Cells that Infect Naive Mice. PNAS 108(27):11205–11210.

Kay, J.G. and S. Grinstein. 2011. Sensing Phosphatidylserine in Cellular Membranes. Sensors 11: 1744-1755

Reefman, E., J.G. Kay, A.P. Manderson, S.M. Wood, C. Offenhäuser, D.L. Brown, S. Roy and J.L. Stow. 2010. Cytokine Secretion is Distinct from Secretion of Cytotoxic Granules in NK Cells. J Immunol. 184:4852-62

Kockx, M., D.L. Guo, M. Traini, K. Gaus, J.G. Kay, S. Wimmer-Kleikamp, C. Rentero, J.R. Burnett, W. Le Goff, M. Van Eck, J.L. Stow, W. Jessup and L. Kritharides. 2009. Cyclosporin A Decreases Apolipoprotein E Secretion from Human Macrophages via a Protein Phosphatase 2B-dependent and ATP-binding Cassette Transporter A1 (ABCA1)-independent Pathway. J Bio Chem. 284(36): 24144-24154

Desclozeaux, M., J. Venturato, F.G. Wylie, J.G. Kay, S.R. Joseph, H.T. Le and J.L. Stow. 2008. Active Rab11 and Functional Recycling Endosome are Required for E-cadherin Trafficking and Lumen Formation during Epithelial Morphogenesis. Am J Physiol Cell Physiol 295: 545-556

Huynh, K.K., J.G. Kay, J.L Stow and S. Grinstein. 2007. Fusion, Fission and Secretion during Phagocytosis. Physiology 22: 366-372

Kockx, M., D.L. Guo, T. Huby, P. Lesnik, J.G. Kay, T. Sabaretnam, E. Jary, M. Hill, K. Gaus, J. Chapman, J.L. Stow, W. Jessup and L. Kritharides. 2007. Secretion of Apolipoprotein E from Macrophages Occurs via a Kinase A- and Calcium-Dependent Pathway along the Microtubule Network. Circ Res 101 (6): 607-616

Manderson, A.P., J.G. Kay, L.A. Hammond, D.L. Brown and J.L Stow. 2007. Sub-compartments of the Macrophage Recycling Endosome Direct the Differential Secretion of IL-6 and TNFα. J Cell Bio 178 (1): 57-69

Beck, K.E., J.G. Kay and J.E.A. Braun. 2006. Rdj2, a J Protein Family Member, Interacts with Cellular Prion PrPC. Biochem Biophys Res Commun. 346: 866-871

Kay, J.G., R.Z. Murray, J.K. Pagan and J.L. Stow. 2006. Cytokine Secretion via Cholesterol-rich Lipid Raft-associated SNAREs at the Phagocytic Cup. J Bio Chem. 281(17): 11949-11954

Murray, R.Z., J.G. Kay, D.G. Sangermani and J.L. Stow. 2005. A Role for the Phagosome in Cytokine Secretion. Science 310: 1492-1495

Miller, L.C., L.A. Swayne, J.G. Kay, Z.P. Feng, S.E. Jarvis, G.W. Zamponi and J.E. Braun. 2003. Molecular Determinants of Cysteine String Protein Modulation of N-type Calcium Channels. Journal of Cell Science 116: 2967-2974

Swayne, L.A., C. Blattler, J.G. Kay and J.E.A. Braun. 2003. Oligermisation Characteristics of Cysteine String Protein. Biochem Biophys Res Commun. 300: 921-926.

Magga J.M., J.G. Kay, A. Davy, N.P. Poulton, S.M. Robbins, J.E. Braun. 2002. ATP dependence of the SNARE/caveolin-1 interaction in the hippocampus. Biochem Biophys Res Commun. 291(5): 1232-1238.

Greene, A.E., J.G. Kay, L.G. Stehmeier and G. Voordouw. 2002. Microbial community composition at an ethane pyrolysis plant site at different hydrocarbon inputs. FEMS Microbiology Ecology 40(3): 233-241

Greene, E.A., J.G. Kay, K. Jaber, L.G. Stehmeier and G. Voordouw. 2000. Composition of Soil Microbial Communities Enriched on a Mixture of Aromatic Hydrocarbons. Appl. Environ. Microbiol. 62: 5282-5289