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 About Oral BiologyFaculty Info     July 22, 2014  

Schifferle, Robert M.A., D.D.S., M.M.Sc., Ph.D. Associate Professor, Department of Periodontics and Endodontics; Associate Professor, Department of Oral Biology

Address:
318 Foster Hall
Buffalo, NY 14214
(716)829-2013
res@buffalo.edu - Faculty Home Page

Faculty Research Profile

Bacterial polysaccharides and lipopolysaccharides of Porphyromonas gingivalis. Bacterial virulence may be enhanced by the presence of a polysaccharide capsule or by lipopolysaccharide. The polysaccharide capsules often act to inhibit phagocytosis, allowing for evasion of host defense mechanisms. Our laboratory is engaged in the study of polysaccharide and lipopolysaccharide of P. gingivalis. Polysaccharide and lipoplysaccharide are released from the bacterial cell surface and purified by a variety of techniques. The purified components are then characterized chemically and immunologically. The ability of these components to function as immunogens and as activators of the serum complement system is under investigation. Current investigations are also evaluating the association to periodontal disease and the capsular polysaccharide serotype.